A0A1D8AR79 · A0A1D8AR79_9BACT

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

110131002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site123ATP (UniProtKB | ChEBI)
Binding site141-145ATP (UniProtKB | ChEBI)
Binding site644ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      Verru16b_00422

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • IG16b
  • Taxonomic lineage
    Bacteria > Verrucomicrobiota > Opitutia > Opitutales > Opitutaceae > Lacunisphaera

Accessions

  • Primary accession
    A0A1D8AR79

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain26-722SecA family profile
Domain125-284Helicase ATP-binding
Domain566-722Helicase C-terminal

Sequence similarities

Belongs to the SecA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,013
  • Mass (Da)
    114,897
  • Last updated
    2017-01-18 v1
  • MD5 Checksum
    95A8983271F6864251C260B4C3F96649
MHFEGVDLPFAKAQREGFTQPLSMLSFILKKFAGRHHRKYIEKCRPIVARINEFEQQYQQLTEEQLRAKTEEFRARVKGGETLDQILPEAFAAVKNAARRMCGRSFTVCDHELVWEMVHFDVQLIGGMTLHEGRIAEMATGEGKTLVATLPLYLNALTGKNTQLVTVNDYLARRDSEWMGHLYNFLGISVGCIQQQMHSEQRREMYGRDITYGTASEFGFDYLRDNGMATRKENQVQRDHFYCIVDEIDSILVDEARTPLIISGPAPIEREQPFTRLKPGVEQLVAAQLKLINHLVKDASDLLEKPALTPDERQIAAMKLLQVKLGMPKNKQLLRLQENPEWRKLLDKTDVEMHSDFNKTELYKYKEELFFVIDEKNHQADLTEVGRKKLRPDDPDAFVLPDLASLFIDIEKDTTKSPEEKEQAKRDAQNRYEVVSEDIHALSQLLRAYSIYERDVEYVVQEGKVVIVDENTGRIMSGRRWSDGLHQAVEAKENVTIERETRTYATVTIQNYFRMYEKLAGMTGTAETEATEFNEIYRLAVTQIPTNKPGIRVDLNDSIFKTRRDKYNAVVKQIQEAQARGQPVLVGTVTVEQSEVLSRMLKRANVIHTVLNAKFHQQEAEIVTRAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLFVVGTERHESRRIDRQLRGRCSRQGDPGQTKFFLSLEDDLMRLFLQGNLASKIMEGSMQEGEELEHKWLNYSIESAQKKVEQQNFSIRKRLLQYDDVLNKQREVIYGIRNAALHSDRPKDIIFEMIEEEIASRLEAANYGGKGDANATNLEALVGWLNSHFPVSAKVDELTGDLETLLKALVERIRKAYALKESVEDQAALGGLERYIVINAIDHHWQEHLTEMEELRRSIGLRSYGQKDPLSEYKGEAFRFFEELMNNVRLQICTSLFRSATNRDAFENLFAILSRSARMQGPAAAPTALGAAAASAAPAGEAPAAAAPEITLPAVTIRRETPKVGRNDPCPCGSGKKFKNCHGA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP016094
EMBL· GenBank· DDBJ
AOS43379.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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