A0A1D1VIH3 · A0A1D1VIH3_RAMVA
- ProteinOctanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial
- GeneRvY_10829
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids251 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Catalytic activity
- octanoyl-[ACP] + L-lysyl-[protein] = N6-octanoyl-L-lysyl-[protein] + holo-[ACP] + H+
Pathway
Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.
Features
Showing features for binding site, site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 92-99 | substrate | |||
Site | 156 | Lowers pKa of active site Cys | |||
Binding site | 159-161 | substrate | |||
Binding site | 172-174 | substrate | |||
Active site | 190 | Acyl-thioester intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | lipoyl(octanoyl) transferase activity | |
Biological Process | protein lipoylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOctanoyl-[acyl-carrier-protein]:protein N-octanoyltransferase LIPT2, mitochondrial
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Tardigrada > Eutardigrada > Parachela > Hypsibioidea > Ramazzottiidae > Ramazzottius
Accessions
- Primary accessionA0A1D1VIH3
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length251
- Mass (Da)28,206
- Last updated2016-11-30 v1
- ChecksumB690C8E4291324D8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BDGG01000005 EMBL· GenBank· DDBJ | GAU99892.1 EMBL· GenBank· DDBJ | Genomic DNA |