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A0A1C5Q3J8 · A0A1C5Q3J8_9CLOT

Function

function

Catalyzes the conversion of lactate to pyruvate.

Catalytic activity

Activity regulation

Allosterically activated by fructose 1,6-bisphosphate (FBP).

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.

Features

Showing features for binding site, active site.

132850100150200250300
Type
IDPosition(s)Description
Binding site25-30NAD+ (UniProtKB | ChEBI)
Binding site29NAD+ (UniProtKB | ChEBI)
Binding site50NAD+ (UniProtKB | ChEBI)
Binding site55NAD+ (UniProtKB | ChEBI)
Binding site80NAD+ (UniProtKB | ChEBI)
Binding site94-95NAD+ (UniProtKB | ChEBI)
Binding site97substrate
Binding site103substrate
Binding site110NAD+ (UniProtKB | ChEBI)
Binding site116NAD+ (UniProtKB | ChEBI)
Binding site133-135NAD+ (UniProtKB | ChEBI)
Binding site135-138substrate
Binding site158NAD+ (UniProtKB | ChEBI)
Binding site163-166substrate
Binding site168beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Binding site183beta-D-fructose 1,6-bisphosphate (UniProtKB | ChEBI); allosteric activator
Active site190Proton acceptor
Binding site245substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular FunctionL-lactate dehydrogenase activity
Biological Processglycolytic process
Biological Processlactate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-lactate dehydrogenase
  • EC number
  • Short names
    L-LDH

Gene names

    • Name
      ldh_1
    • Synonyms
      ldh
    • ORF names
      SAMEA3545261_00960
      , SAMEA3545398_01306

Organism names

  • Taxonomic identifier
  • Strains
    • 2789STDY5608853
    • 2789STDY5834935
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium > environmental samples

Accessions

  • Primary accession
    A0A1C5Q3J8

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-43Helical

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue236Phosphotyrosine

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-157Lactate/malate dehydrogenase N-terminal
Domain160-326Lactate/malate dehydrogenase C-terminal

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    328
  • Mass (Da)
    35,402
  • Last updated
    2016-11-02 v1
  • MD5 Checksum
    99046313C4DF4A281EEA576FC5238B23
MKKIIKGEIITKKQTINSKKAVMIGCGFVGSASVFALMQSGLFTEIVLIDADKDKADGEAMDISHGIPFASPMKIYAGDYDDVVDAAIVIISAGAGQKPGETRLDLVNKNVAIFKSIIPEIAKRNFAGIMLVVANPVDILTQVAIKLSGLPENRVIGSGTVLDSARLRYKLGEHLSVDSRSVHAFILGEHGDSEVVAWSSANVSGVPLSEMCEMRGHYKHKENTEEIATAVKNSAYEIINKKHATYYGIAMSVKRICEVIMRDEKSILPISHMIHGIYDIDGVSLSMPAIVGANGVESDVPINLNGEEALKLKESADALKKIIEKIEL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FMER01000005
EMBL· GenBank· DDBJ
SCH43736.1
EMBL· GenBank· DDBJ
Genomic DNA
FMGK01000006
EMBL· GenBank· DDBJ
SCI90480.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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