A0A1C2BXZ3 · A0A1C2BXZ3_9ALTE

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      A9165_14230

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • HH-ZS
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Alteromonadales > Alteromonadaceae > Alishewanella

Accessions

  • Primary accession
    A0A1C2BXZ3

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-35Helical
Transmembrane56-78Helical
Transmembrane84-103Helical
Transmembrane115-136Helical
Transmembrane177-197Helical
Transmembrane221-243Helical
Transmembrane263-286Helical
Transmembrane293-315Helical
Transmembrane321-354Helical
Transmembrane366-389Helical
Transmembrane409-427Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-431Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    447
  • Mass (Da)
    49,170
  • Last updated
    2016-11-02 v1
  • MD5 Checksum
    3BD664855F9B4F606CB6BF6717D0F0FB
MHDASWRDLPPPTPFYRWMVLLFISLAMFGNYYIYDSLWPILDLLREQRGFSYQQIGWLSTAYNIAALLVLLAGGYLIDRWGTKRAITLFALICLFAAIVTAWSPNFEMMLAGRFLLGLGAEPMIVAVTTVMAKWFKGKELSFAFGINLSIARLGSTAADWSTGFASPLYANWQDPLWLATAVAGISVSAAILYWILERRAEGRYSLGVAENNEKLEFKGLYSFSASYWYVVALCVVFYATVFPFRSFAIDYFQQAHGLDRTAAGILSSILPVSAIIATPLFGLWVDRVGRRALFMAIGSLVMLPLFLIVTYAPAGPLVGISIPLIGSAVVPLTLLLVIILLGIVFSLIPAVMWPSVAYIVDGRRLGSAFALMTFCQQIGMAAIPQAIGYFNDKFLAGPENIAGYTPGMWLYTALASLGLYFSYKLWRTEQGPTGHGLDSITSKSAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LZEJ01000042
EMBL· GenBank· DDBJ
OCW95134.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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