Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A1B2TT48 · A0A1B2TT48_PIG

  • Protein
    Cellular tumor antigen p53
  • Gene
    TP53
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for site, binding site.

138650100150200250300350
Type
IDPosition(s)Description
Site112Interaction with DNA
Binding site168Zn2+ (UniProtKB | ChEBI)
Binding site171Zn2+ (UniProtKB | ChEBI)
Binding site231Zn2+ (UniProtKB | ChEBI)
Binding site235Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcentrosome
Cellular Componentendoplasmic reticulum
Cellular Componentmitochondrial matrix
Cellular ComponentPML body
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionmetal ion binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processapoptotic process
Biological Processprotein tetramerization
Biological Processrhythmic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cellular tumor antigen p53

Gene names

    • Name
      TP53

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    A0A1B2TT48

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link284Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords

Expression

Gene expression databases

Interaction

Subunit

Binds DNA as a homotetramer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain6-30p53 transactivation
Region57-76Disordered
Domain92-281p53 DNA-binding
Region279-315Disordered
Compositional bias298-312Polar residues
Domain312-349p53 tetramerisation
Compositional bias345-361Basic and acidic residues
Region345-386Disordered

Sequence similarities

Belongs to the p53 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    386
  • Mass (Da)
    42,862
  • Last updated
    2016-11-02 v1
  • MD5 Checksum
    18E6CDCAEFE856D950895C2928319515
MEESQSELGVEPPLSQETFSDLWKLLPENNLLSSELSLAAVNDLLLSPVTNWLDENPDDASRVPAPPAATAPAPAAPAPATSWPLSSFVPSQKTYPGSYDFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTEVVRRCPHHERSSDYSDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNFMCNSSCMGGMNRRPILTIITLEDASGNLLGRNSFEVRVCACPGRDRRTEEENFLKKGQSCPEPPPGSTKRALPTSTSSSPVQKKKPLDGEYFTLQIRGRERFEMFRELNDALELKDAQTARESGENRAHSSHLKSKKGQSPSRHKKPMFKREGPDSD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias298-312Polar residues
Compositional bias345-361Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU705625
EMBL· GenBank· DDBJ
AOC89043.1
EMBL· GenBank· DDBJ
mRNA
KU705626
EMBL· GenBank· DDBJ
AOC89044.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help