A0A1B2TT48 · A0A1B2TT48_PIG
- ProteinCellular tumor antigen p53
- GeneTP53
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids386 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 112 | Interaction with DNA | |||
Binding site | 168 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 171 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 231 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 235 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | mitochondrial matrix | |
Cellular Component | PML body | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | metal ion binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | apoptotic process | |
Biological Process | protein tetramerization | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCellular tumor antigen p53
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionA0A1B2TT48
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Cross-link | 284 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | |||
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Binds DNA as a homotetramer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-30 | p53 transactivation | |||
Region | 57-76 | Disordered | |||
Domain | 92-281 | p53 DNA-binding | |||
Region | 279-315 | Disordered | |||
Compositional bias | 298-312 | Polar residues | |||
Domain | 312-349 | p53 tetramerisation | |||
Compositional bias | 345-361 | Basic and acidic residues | |||
Region | 345-386 | Disordered | |||
Sequence similarities
Belongs to the p53 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length386
- Mass (Da)42,862
- Last updated2016-11-02 v1
- MD5 Checksum18E6CDCAEFE856D950895C2928319515
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 298-312 | Polar residues | |||
Compositional bias | 345-361 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KU705625 EMBL· GenBank· DDBJ | AOC89043.1 EMBL· GenBank· DDBJ | mRNA | ||
KU705626 EMBL· GenBank· DDBJ | AOC89044.1 EMBL· GenBank· DDBJ | mRNA |