A0A178B0Y2 · A0A178B0Y2_9PLEO

Function

function

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

111131002003004005006007008009001,0001,100
Type
IDPosition(s)Description
Binding site597-604ATP (UniProtKB | ChEBI)
Active site978
Active site1021

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Molecular Functionsingle-stranded DNA binding
Biological Processcellular response to oxidative stress
Biological Processchaperone-mediated protein complex assembly
Biological Processmitochondrion organization
Biological Processoxidation-dependent protein catabolic process
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease homolog, mitochondrial
  • EC number

Gene names

    • Name
      PIM1
    • ORF names
      IQ06DRAFT_333368

Organism names

  • Taxonomic identifier
  • Strain
    • SRC1lsM3a
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Massarineae > Massarinaceae > Stagonospora

Accessions

  • Primary accession
    A0A178B0Y2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer or homoheptamer. Organized in a ring with a central cavity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

Type
IDPosition(s)Description
Region1-27Disordered
Region59-103Disordered
Compositional bias64-83Basic and acidic residues
Region121-161Disordered
Domain178-444Lon N-terminal
Region278-314Disordered
Compositional bias284-307Polar residues
Coiled coil417-457
Compositional bias815-837Basic and acidic residues
Region815-850Disordered
Domain886-1072Lon proteolytic
Compositional bias1088-1105Basic and acidic residues
Region1088-1113Disordered

Sequence similarities

Belongs to the peptidase S16 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,113
  • Mass (Da)
    122,308
  • Last updated
    2016-09-07 v1
  • Checksum
    1DCE5F6701CE9368
MPSSNLPWRAALRQASRSSTRVPTSRASARFLPAQCTASLVSRYPLTCPSPPAALLAHRSFSTTLSQRKEKDPDKPADPVDEDVEKPKEEDAEAAELTPEQAKSFKVLQDKIEELEARAELEARNRSSESAPSRTGSGRGSAAGGSGDDSGGDPGGFVKKRKSSASVKASIPEVYPQIMAIPLLKRPLFPGFYKAITIRDREVGEAIIDMIKRGQPYIGAFVCTDDSVDKDVIDNIDDVYNIGTFCQVTSAFPLATGVGETGYAMTCVLYPHRRIKMTGLTPPPAEESDTQNTESVAESTLEHATANEPPANQAKGDVVASFEEASEEDNVPALLKGRRVSVADVVNVVEEPFDMKTNKNISLLVNEIVNTFKGVALLNPAFREHISTFSIHATMNVGEDPVKLADFAAAVAQGEGAAELQDVLEELNVEARLKKSLELLKKELLSAELQKKIADDTNAKVMKKNREYILMEQMRQIKRELGIESDGKEKLVEKFTEKAAKLAMPEPVRKVFDEEMSKLAGLDANGSEFNVTRNYLDWLTQLPWGLRSAETFAIKHAREVLDEDHHGLKDVKDRILEFIAVGKLRGTVEGKILCLVGPPGVGKTSIGKSIARALNRQYYRFSVGGMYDVAEIKGHRRTYVGALPGRIIQALKKCQTENPLVLIDEVDKMGRMSNHGDPASALLELLDPEQNNSFLDHYLDVPVDLSKVLFVCTANMEDTIPQPLLDRMEVIRLSGYVSDEKIAIAEKYLAPVAKELSGLKDADVVLQNDAIVELINKYCRESGVRNLKKHIEKVYRKAALKIVADVGEDALPEAEALTEEGKEAQKESEKDQTDPNVTPENIDKQATEKPRVALKVPDSVHVSITQENLKDYVGPPVYISDRLYDTTPPGVAMGLAWTSMGGSALYIESIVQNVLSAASHGGLERTGSLRDVMKESTGVAYSYAKSIMARDYPKNKFFEHARIHLHCPEGATPKDGPSAGITMTSSLLSLALDTPIKEGVAMTGEITLTGKVLRIGGLREKTVAARRAGATTVIFPKDNMSDWLELPENIKEGIEGKPVTWYSDVFKVVFPNVDRDVVNKLWKDELKSKKGDRKRKEQKRKGEEEEESGEDDD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias64-83Basic and acidic residues
Compositional bias284-307Polar residues
Compositional bias815-837Basic and acidic residues
Compositional bias1088-1105Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV441708
EMBL· GenBank· DDBJ
OAL03243.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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