A0A178B0T8 · A0A178B0T8_9PLEO

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      IQ06DRAFT_217184

Organism names

  • Taxonomic identifier
  • Strain
    • SRC1lsM3a
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Massarineae > Massarinaceae > Stagonospora

Accessions

  • Primary accession
    A0A178B0T8

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane51-70Helical
Transmembrane123-142Helical
Transmembrane149-169Helical
Transmembrane216-239Helical
Transmembrane273-294Helical
Transmembrane314-335Helical
Transmembrane342-362Helical
Transmembrane368-387Helical
Transmembrane408-425Helical
Transmembrane437-460Helical
Transmembrane502-524Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region24-45Disordered
Compositional bias31-45Polar residues
Domain57-459Major facilitator superfamily (MFS) profile

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    529
  • Mass (Da)
    57,639
  • Last updated
    2016-09-07 v1
  • Checksum
    C19385B4F1EB34AD
MTAQKGDQSDVVVGQKEQDGLAKTMTTEIAVASEEAPSNGQENRKESLVPLRMKLISILLVTAVGFGSHWSSGVTGAMKSTLKKKLHINNAEYAVLEASEDFMKTALILVSGLVTDRIGGASAMLWGNAIYSVGAILIAAATTVRSYRFMIFGVVVQALGDIATQVAQYKVFSSWFAPSNGFASTLGFELGIGKIGSFVGKATANVIAKKTGDFSWVYWTAVFMNIFTNVVTLVFWFFTRWCQKRYGGMQDPATGEKLTEKSKKFELGKILRLPWTFWAVVAFSLFQTSTAMVYSQNATEMAEQRFNVSAITAGWYSAMSQYFGFFLVPLIGVFVDLMGNRITLMVVCGLGMLLSMCLAAWGPSVAGTAASFGIFAVASSFGPTVIIDSIRTSMRYQEVFGSGYAIKIAINNSMNIILRIVTGVIQDRDNNSYDNVVIIYVAFAAGSVIVAGIFMAYSYFNIDAMILQWTKKQRKSNGHLIVEKREESETNAAGIKNRKSGLVLFAALFTLIAGAWAAYFWGIATHNNS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias31-45Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV441709
EMBL· GenBank· DDBJ
OAL03203.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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