A0A178ACH0 · A0A178ACH0_9PLEO

Function

function

ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA helicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular Functioniron-sulfur cluster binding
Molecular Functionisomerase activity
Molecular Functionmetal ion binding
Molecular Functiontransmembrane transporter activity
Biological ProcessDNA damage response
Biological Processestablishment of sister chromatid cohesion
Biological Processnucleobase-containing compound metabolic process
Biological Processoligopeptide transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase CHL1
  • EC number
  • Alternative names
    • ATP-dependent DNA helicase chl1
    • Chromosome loss protein 1
    • DNA 5'-3' helicase CHL1

Gene names

    • ORF names
      IQ06DRAFT_285582

Organism names

  • Taxonomic identifier
  • Strain
    • SRC1lsM3a
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Massarineae > Massarinaceae > Stagonospora

Accessions

  • Primary accession
    A0A178ACH0

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein
Nucleus

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane955-975Helical
Transmembrane987-1004Helical
Transmembrane1010-1029Helical
Transmembrane1069-1090Helical
Transmembrane1096-1115Helical
Transmembrane1175-1193Helical
Transmembrane1213-1232Helical
Transmembrane1253-1275Helical
Transmembrane1287-1309Helical
Transmembrane1321-1340Helical
Transmembrane1352-1372Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain6-408Helicase ATP-binding
Region114-138Disordered
Region472-492Disordered
Compositional bias864-886Polar residues
Region864-891Disordered
Region1381-1407Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,407
  • Mass (Da)
    155,170
  • Last updated
    2016-09-07 v1
  • Checksum
    118E6A15B5A7A3E3
MDDDNRERDYHHPYEPYDIQKEFMHAVYQCLETGKVGIFESPTGTGKSLSLICGSLTWLRDNKRRTFEDGFVLDATVGDEPDWIVEHAQRQKKEEALRRKRDLNDRIAKVKAKEKRAKERYENGEPRYKRQKVSDIEKSGTDDEAQFLLDDYESDGEHAQAGKFAAFDDTGLSADTQALMEQLGFSTGTTKSNEDDSTDETKIFFCSRTHSQLTQFSSELTRVKMPSALETVVDEVSTDTLVEDVKHLTLGSRKNLCINSKVNRLGSATAINERCVELQQATSADKKCPHMPKKEDEPLLHDFRDHALAKVRDIEDLALLGKKLGVCPYYASRPVVQHCESAREALGLSLKDHVVIIDEAHNLMDAIAGIYSTAVTLDQVEQARAQLTVYLQKFRNKLKGKNRVYVAQTIRILDSILAYLKTIQADAKATDGLVDMLSIMSGRGVDQVNIFKLNIYLQESRLARKVDGYTTYSESGPKDAEHGLRKPQERAPRQNVPALMHVQAFLLSLMNPSAEGRFFFSKEDSCVTLRYMLLDPTYHFQDIVEEARAVVLAGGTMSPMSDYKQHLLAYLDTSKIMTLSCGHVIPPSNLLAVPIVRAASGSEFDFTFESRNKEKTMIDLGHAILAMAQHIPDGVVVFFPSYSYLDTCIAGWKRIIATGSKHTLWDRFIQTKPVFLEQRCQHNASQPPINKDAAVDSVLTAYSAAIASGLGRGALLFAVIGGTLSEGINFSDALGRGVVVVGLPFPNPHSAEWKAKMQYISAKETKRGGDGKGAARDFFENACMRAVNQCVGRAIRHKGDYAAIMMLDRRYGTKRIQDKLPKWIRGSLTAGLGARDVETELDSFFASKASSSLGAYTTVAQTDENDSIPIHRRSSTSSSNQGIPDFSHPTAVDDASSLPQLSAPLPLPAYLIATVELCERFAYYGLSGPFQNYISSSPTSTPAGVLGLGQARATALTNLFQFWCYVTPLLGAVVADEWMGKYGAIRGFSVIYMLGIIILFLSSLDLVPGTAMPGLVVAMTVIGLGTGGIKPNVSPFIAEQVTFSSDFVSMNSRSGKKEVVSHALTMQKVFTVFYVCINVGSVGAMLTTLLELHVGFWAAYLLPLLVFILGFAILVRSSDRYVIRPSQGGVLRDCMSILYVCARNGFRLDAARGAGRWDDEFVDELRTALRACKIFMFYPIYWLAFSQMMNNFVSQASHLSLHSLPNDLLPTLNPLSLLALIPIFTHIIYPALSRLSHLLRPQQPKRPLSPISRISIGFLLVSLSMFSASLLQHFITTSPPKSIHVAWQAPAYILIAASEICASITGLEVAYARAPASLKSVVMSLFLLTSAGGSVLGVLVSPLASKEEWVGGMYFGLGVLVGGAGVVFWWVFRHDDDHDQGVRGKLGEEDGEGIELGERRTSSLELR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias864-886Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV441724
EMBL· GenBank· DDBJ
OAK94589.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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