A0A178ACH0 · A0A178ACH0_9PLEO
- ProteinATP-dependent DNA helicase CHL1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1407 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | iron-sulfur cluster binding | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Molecular Function | transmembrane transporter activity | |
Biological Process | DNA damage response | |
Biological Process | establishment of sister chromatid cohesion | |
Biological Process | nucleobase-containing compound metabolic process | |
Biological Process | oligopeptide transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase CHL1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Massarineae > Massarinaceae > Stagonospora
Accessions
- Primary accessionA0A178ACH0
Proteomes
Subcellular Location
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 955-975 | Helical | |||
Transmembrane | 987-1004 | Helical | |||
Transmembrane | 1010-1029 | Helical | |||
Transmembrane | 1069-1090 | Helical | |||
Transmembrane | 1096-1115 | Helical | |||
Transmembrane | 1175-1193 | Helical | |||
Transmembrane | 1213-1232 | Helical | |||
Transmembrane | 1253-1275 | Helical | |||
Transmembrane | 1287-1309 | Helical | |||
Transmembrane | 1321-1340 | Helical | |||
Transmembrane | 1352-1372 | Helical | |||
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 6-408 | Helicase ATP-binding | |||
Region | 114-138 | Disordered | |||
Region | 472-492 | Disordered | |||
Compositional bias | 864-886 | Polar residues | |||
Region | 864-891 | Disordered | |||
Region | 1381-1407 | Disordered | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,407
- Mass (Da)155,170
- Last updated2016-09-07 v1
- Checksum118E6A15B5A7A3E3
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 864-886 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KV441724 EMBL· GenBank· DDBJ | OAK94589.1 EMBL· GenBank· DDBJ | Genomic DNA |