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A0A166UY01 · A0A166UY01_9GAMM

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

GO annotations

AspectTerm
Molecular Functionaspartate kinase activity
Molecular FunctionATP binding
Molecular Functionhomoserine dehydrogenase activity
Molecular FunctionNADP binding
Biological Processhomoserine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processphosphorylation
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00034UER00015
    • UPA00050UER00063
    • UPA00051UER00462

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional aspartokinase/homoserine dehydrogenase

Including 2 domains:

  • Recommended name
    Aspartokinase
  • EC number
  • Recommended name
    Homoserine dehydrogenase
  • EC number

Gene names

    • ORF names
      N475_23460

Organism names

Accessions

  • Primary accession
    A0A166UY01

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-271Aspartate/glutamate/uridylate kinase
Domain434-562Aspartate/homoserine dehydrogenase NAD-binding
Domain579-774Homoserine dehydrogenase catalytic

Sequence similarities

In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    782
  • Mass (Da)
    86,256
  • Last updated
    2016-07-06 v1
  • MD5 Checksum
    DEB72FAFB4A1219A3C385B21802EA039
MTKVVHKFGGSSLSSATRYKAVANIVLGHCKAGDCVVVSAAGKTTNTLVKLWQSYVQQDDKAFNDILLQVENHQRQLLSELFSEASAQSLRSQLQDELVTIAKAANARTLHEATLLAHGEVWSARLLAHLLNTLNVSASDVDARGLFAQHQGQLLHAQNKQACLSQIDTSKINVVTGFIAADCDGNTITLGRNGSDYSATLLANYIDAEAVSIWTDTQGVFSTDPRKVGSAVKYPKVCRVQANLLARLGNPVLHAKTLSPLKDTNIKLQVRSSYEPEIIGTEIVKQGYSKEKRFITTFEELDLIRVEELVNGEVRTLSQLIQHSIHHFSKGGEDYLLVPSNDTHAVATHLQGRGNIVETHLRGVALVAPEYEITQLSQQAAVVLEQQDVVIRFTHSDSNYALFLTDQSIDSDVLAILHDKLVNKGREIAVIIAGLGNVGEVFVEQCQAQIEKLQAAFDLKVVALLRSKEMLFCPSGISISNWQQQWRSESQHYSQADLLERISELDYEHKVIIDITASDAFSDMYPSFVEQDCHLISANKYAGTAPRNWYAKLLEQLQERNLFWRYNTSVGAGLPINFALADLQNSGDKVTRIEGVFSGTLSWLCSSYDGSQPFSDLVIKAQQMGYTEPDPREDLSGRDMQRKLLILARDLGLELDVEDIELEPLMPTHLAQGDWGAFLANKQDLDVFYAQRAEQAARDGKALRYTGALDIDEHGKVAAKVGIAYVESGSAIANLTPGDNIFVITSQWYQQNPLVIQGPGAGKEVTAAGIHSDLYWLTQNLK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AUYB01000140
EMBL· GenBank· DDBJ
KZN31501.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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