A0A165YU28 · A0A165YU28_9AGAM

Function

function

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Biological ProcessDNA repair
Biological Processintracellular signal transduction
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase Tel1
  • EC number

Gene names

    • ORF names
      FIBSPDRAFT_922456

Organism names

  • Taxonomic identifier
  • Strain
    • CBS 109695
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Atheliales > Atheliaceae > Fibularhizoctonia

Accessions

  • Primary accession
    A0A165YU28

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Associates with DNA double-strand breaks.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region179-254Disordered
Compositional bias183-210Acidic residues
Compositional bias226-254Polar residues
Region755-780Disordered
Domain1979-2585FAT
Region2588-2608Disordered
Domain2703-3026PI3K/PI4K catalytic
Domain3031-3062FATC

Sequence similarities

Belongs to the PI3/PI4-kinase family. ATM subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,062
  • Mass (Da)
    343,194
  • Last updated
    2016-07-06 v1
  • Checksum
    DFBCC60E51401521
MSNLDKVIRLLKSEKIKERGEGLASLRTVFARDAAVASLDHAGNGKAWLLVFQALFGCVLNEKAALTKTTKAGHSIKITPSAAASRRLGDAAATVRWLTERSVHLLNKKVTTSLIAHLRQVVINHGELLAPVALDYVKALRCVAGWTPHLEHMSEDDWVDIVQLAWNIVLGDPIRQTLDDGEGVELEESPDRDVDDDDMYMDDESDGDEGETTSNQSRKRRRAPSATPRPSSSKHTFKSTQQASQRKASHSHAPSLEQIECTALLATMLRFPGAPWLSHKYPLLASSLLRRFRRFLEIYPSDTSMHHDYVLSLAAALSQLSLNKKQDVTAFAQVAWNGLVGLWGTKNKRMKEGLVGVLHVLLPFYISNAGFASSTAVGFDCSEGIGRLFHLLSGEAESRWGIDGLSLDAIRLEIVASGKHEQRHQGAFQKSTFRAGWNFDATQALSWVMLQLQADCAYTLFQKSETLQPASQLKSESKRMRIENPITSLLASIQLQAASNIRAFHIQTLLFFIDTHWATLHDSLQEEVMVTLQQFVSFDDPVVQSWAFLCFAAIAYADDAASRCRDASVWDPIWTHAMRRANVPTVCRAACHAAHVLLSHWHSSSTSQTAHTRLLTSQLVLMEIEAFAKDMEVQGPSFPYDSVCVFLVECLRVSSKDVRLYKMQLEEKVIGWLIDCWSIRDAGAVVAGDQSRMPPHTVRDVLALMESACGVSKRSDLVCELGLPECFIVGTVVDDQQTHVIRNFLLHATLPSFHRSTKDASDDPALDRLPQPLAGESDLAPPRVRERRLSTFLLKSLEALISDWETISGTNAQPAGEKGRRSLDFAVLALSFEGMLVLNGTKATRRVVQASFKLLGLVIPMLTKRTWTAHEISLVIKGLDPLFCDEESDDRVEWVALVPPNKGTGIQTRRLQDLQSDLRVRSNENRILRRDLQRIIWTGIDAQEASVVIMSGLREVLRAASGSTSSTEPVGDTEDRDGFEPIRTNHVIAQSADVGQQSNDSQSNQSIAATCTSLLSVVPVLQSLSGEPTRDKAITDLVLQCSAEKFLLLGPAYFSKVHRRVLYMSLKVLGELLEKFEGILQEYEYSRSEQLQLLVTQFLRSTLHLWKQDSADPDEVGDNIGQLCHWLSNALHKQKIRSWRTRDVVIQFLQQYIVEDPAQSIWAGDAESSPPPMDLLPMLGDDRDVRIRFRIASSTAQLFSVTQEDPSDLYARIKQWLTNDIDDYEHMLTRMLTLGNVMIVSSAVRRAPYFHLLEGVFINPQYNHHVQTILVAVSERLGLQHFCQLFEAYASQIAFSIRQAGTDILTIPPHLLGYQGRRECAEATFRSFTPSNIMAGGSTPQSIEHGQRLFKAHCKLLQKSPTEGIRDCFGDIVGYQIAIWCDSVLDQDDHTALLGDLKEQIRVRTLLVHDQDGLEAVLQDNVDGIVTAILRTLADQDFTSNGAIVQALRSAGTSDHVIQAFQKLTCFRDLRDVALHRPNLPTYSTQTILRAVERVHQLVPDIDARATTYHVLRQLFADVQHTPLVNEQIRLINAISLWAALYSEDFKDLTLLHTLINGATSLLGHSDLARAAQSILDWCFTHYRAVGQKGTRLTDILVRICCIGHEYAIAQDSEIANMGRDILLWIDNQALQMYKISVLRNQVNRALPAWPHQPSAELSRLSSNIDSNITSTILNGHRISPNKFRLVRRFRDLALSGKYNAKQFAETDFWRLKESIPSGEQLQKEDVDAFAGLLALHRGRIQSFTSEQSTSQSLRARHIGIQKRGSNSTADDTSPQHVIVQAVLDMLDANMSSQVHVVYTTMRLIMSLAASKALQLQSWPVEYRTELDYLQKYPQTPMSRTHRDLTELAAAKFDIETTADFSTWISEFTILLSDVLVASDPFYAQITDLLASDVEFAEQVLPVLVHTVLQQEPFTSDRLESSFCHCLSAYFTKILSSESTDVSCLRCIVDVVLHLRNFYPKDCKDPLGHEQWLDVNYILLSRNAVTCGAYTTALLFLELAAEHQASDDKAGDVEQIMFDIYNHIDEPDGFYGIQTTDLRQFLTKRLHHEHQWEKALRFHGAAIEASSTNTHDSNGLLDSFHAFGFNQLAMETLQGSWMGMGNASSSAMSYKLGWRTDTWDLPDQHGTESRAASIYVALRAVHRERDPHMIDSIIWRALSGEMARLRTLGSENLTEIREVTRNLMCLNEVTQWRMASTQNLISAKRIDLSEWTDFVKMGPDFEFTDLEHIMATRMSLLRSVRHKEQHGQIGTLVAPLTKGLIDIEKQCLVHLSAAARESNQIQIALNSIVRAQSFESSPGFEVSKEFADVLWLQNERKLAVQYLKALLSGDNSSSQSEVANMTRKASLLSRLGEWTSEACLEKPSDISSRFFKPAITFVNGLVSRKDVAFEAECATVYRQCAMFAEHQYLTIVRSPDTVRWRLYIDRKTQEIKQRGEQLSRIFQGSKEFQELTQAQRKAVTLLSQDQTYFEQESGARNAFLEQAIDMYSRSLATSDAFDDDGSLRLCSLWFANFDDIPLQEKVRIALDRVPSRKFVFLAHQLSARLSASSSGQVAQNQTNVHSIISRMCQEHPFHSLYQVFALRANPGQGLTSSTRRQSSRHDISLSQTNRSSAADDIFSRLRGDSTMGSRVQGVENVCKASLQWAVLPIRHDARYGKNMKGPFKVPENIDLLKIKNLQVPVVTVATPIDVTLRYDKCIWIKGFEERFDTAGGVNLPKISVCIGEDGSRHKQLFKGEGNDDLRQDAVMEQVFGLVNIVLKRDRDTRKRELHMRDYIVIPLSSQAGILEFVGNTFPLADWVKNAHTKYRPTDMKSADVVKLLVKTSKECGGATGPMVKVFKEIMLKFQPVMRHYFTEKTKNPMIWYTTRLNYIRSVATASIVGHVLGLGDRHTSNILMDSANGAVVHIDLGIAFDQGKLLGVPERVPFRMTRDMVDGMGISGTQGVFQRCAEETLRVLRDRSGVIMTVLEVFKYDPLHSCGRVPDLTNCRTASDLKIKRAQANASTTSIDMSSGTADEAADRALSSVSRKLDKNLSVEYTVNELIAEATDIANLATIFPGKIPF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias183-210Acidic residues
Compositional bias226-254Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV417690
EMBL· GenBank· DDBJ
KZP09916.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help