A0A165YU28 · A0A165YU28_9AGAM
- ProteinSerine/threonine-protein kinase Tel1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3062 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome, telomeric region | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | histone H2AS1 kinase activity | |
Biological Process | DNA repair | |
Biological Process | intracellular signal transduction | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase Tel1
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Atheliales > Atheliaceae > Fibularhizoctonia
Accessions
- Primary accessionA0A165YU28
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 179-254 | Disordered | |||
Compositional bias | 183-210 | Acidic residues | |||
Compositional bias | 226-254 | Polar residues | |||
Region | 755-780 | Disordered | |||
Domain | 1979-2585 | FAT | |||
Region | 2588-2608 | Disordered | |||
Domain | 2703-3026 | PI3K/PI4K catalytic | |||
Domain | 3031-3062 | FATC | |||
Sequence similarities
Belongs to the PI3/PI4-kinase family. ATM subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,062
- Mass (Da)343,194
- Last updated2016-07-06 v1
- ChecksumDFBCC60E51401521
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 183-210 | Acidic residues | |||
Compositional bias | 226-254 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KV417690 EMBL· GenBank· DDBJ | KZP09916.1 EMBL· GenBank· DDBJ | Genomic DNA |