A0A150AAQ2 · A0A150AAQ2_9BACT

  • Protein
    Bifunctional protein FolD
  • Gene
    folD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site164-166NADP+ (UniProtKB | ChEBI)
Binding site193NADP+ (UniProtKB | ChEBI)
Binding site234NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      AVL50_28825

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • SJP92
  • Taxonomic lineage
    Bacteria > Bacteroidota > Cytophagia > Cytophagales > Flammeovirgaceae > Flammeovirga

Accessions

  • Primary accession
    A0A150AAQ2

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-119Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain122-290Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    296
  • Mass (Da)
    32,030
  • Last updated
    2016-06-08 v1
  • Checksum
    2AF6333B7B5F2373
MQLIDGKATSNAIKQEIAEEVRKLTAAGGKKPHLAAILVGEDGASRTYVNHKVKSCEQVGFDSTLCKFDADITEEKLLQAIEELNNNDDIDGFIVQLPLPKHIDETKVTEAIDPKKDVDGFHPANLGKMMLGLPTFLPATPYGIVQLLDRYNIETSGKKCVIVGRSHIVGTPMSLLMSRNSKVGNCTVTLTHSRTQNLKEECLSADILIVALGKAEFVTADMVKEGATVIDVGITRIEDPSKKSGFSLKGDVKFDEVSEKAGWITPVPGGVGPMTVVSLLMNTLESVKRKSVKETI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LQAQ01000112
EMBL· GenBank· DDBJ
KXX66981.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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