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A0A147IPJ3 · A0A147IPJ3_9SPHN

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site23-28substrate
Binding site55Mg2+ (UniProtKB | ChEBI)
Active site84Proton acceptor
Binding site84Mg2+ (UniProtKB | ChEBI)
Binding site85substrate
Binding site167-170substrate
Binding site190substrate
Binding site195-196substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      NS355_12345

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NS355
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingomonas

Accessions

  • Primary accession
    A0A147IPJ3

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    22,501
  • Last updated
    2016-06-08 v1
  • MD5 Checksum
    3FD3A91F47E4265FC7F2779E84DC0F38
MSGEGNGRQAIRKLTPGKLVLASHNKGKIVEFRELLAPYGMEVIAAGDLDLPEPEETGTTFVANAELKALAAADLSGLPALSDDSGLCVEALGGDPGLFSARWAGPEKDFAMAMRAVEDRLNEEPDMSRAAHFICALAVGWPDGHVEWFEGRVDGTIVWPPRGDKGHGYDPMFQPNGYTETFAEMDQDEKNRISHRADAFGQLVKAVF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LDTF01000068
EMBL· GenBank· DDBJ
KTT97118.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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