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A0A101DCK3 · A0A101DCK3_ARCFL

  • Protein
    Bifunctional enzyme Fae/Hps
  • Gene
    fae-hps
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin.
Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate biosynthesis; D-ribose 5-phosphate biosynthesis.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site18Proton donor
Binding site20substrate
Binding site49substrate
Binding site67substrate
Binding site69substrate
Binding site84substrate

GO annotations

AspectTerm
Molecular Function3-dehydro-L-gulonate-6-phosphate decarboxylase activity
Molecular Functioncarbon-nitrogen lyase activity
Molecular Functionhexulose-6-phosphate synthase activity
Molecular Functionhydro-lyase activity
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Processcarbohydrate biosynthetic process
Biological ProcessL-ascorbic acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional enzyme Fae/Hps

Including 2 domains:

  • Recommended name
    5,6,7,8-tetrahydromethanopterin hydro-lyase
  • EC number
  • Alternative names
    • Formaldehyde-activating enzyme
      (Fae
      )
  • Recommended name
    3-hexulose-6-phosphate synthase
  • EC number
  • Short names
    HPS
  • Alternative names
    • D-arabino-3-hexulose-6-phosphate formaldehyde lyase

Gene names

    • Name
      fae-hps
    • ORF names
      XD40_1738
      , XD48_1576

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 49_2300
    • 49_95
  • Taxonomic lineage
    Archaea > Euryarchaeota > Archaeoglobi > Archaeoglobales > Archaeoglobaceae > Archaeoglobus

Accessions

  • Primary accession
    A0A101DCK3

Proteomes

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-162Formaldehyde-activating enzyme
Region163-3943-hexulose-6-phosphate synthase
Domain175-377Orotidine 5'-phosphate decarboxylase

Sequence similarities

In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    394
  • Mass (Da)
    43,200
  • Last updated
    2016-04-13 v1
  • MD5 Checksum
    204A3343B3A9EF95259F0E3835DD39AF
MEFRIGEALIGEGFEVAHVDLIIGTKDSPAGIAFANALANLSAGHTPLLAVLRPNLITKPPAVIVPKVTVKDMHQAELIFGPAQAAVAKAVADAVEEGIIPRERADEYVVVASVFIHPNAKNKHKIYYYNYGATKLAIKRAMQNFPDVDTVLYEKDRSFHPFVGRKLTKLWDPPYLQIAIDIPDLGEVLKVLEQIPDSDHIVFEVGTPLAKRYGCEVILKLREVKPDAFYILDLKTLDVGNLEARMAADATANAVVISGLAPTSTIVKGIREAEKTGILSYVDMMNVDDPIKRLEEIQKAGVLPNVVELHRAIDSEDKEPPWMLAGKIKEKFSVLVAVAGGIRPENVEEVIAAGADIIVVGRAVTKARDVEGAVRKFMSHMKPDTDQFRIMTDF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LGEQ01000036
EMBL· GenBank· DDBJ
KUJ93055.1
EMBL· GenBank· DDBJ
Genomic DNA
LGEX01000048
EMBL· GenBank· DDBJ
KUK06194.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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