A0A101DCK3 · A0A101DCK3_ARCFL
- ProteinBifunctional enzyme Fae/Hps
- Genefae-hps
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids394 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H4MPT) to 5,10-methylenetetrahydromethanopterin.
Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
Catalytic activity
- 5,6,7,8-tetrahydromethanopterin + formaldehyde = 5,10-methylenetetrahydromethanopterin + H2O
Pathway
Carbohydrate biosynthesis; D-ribose 5-phosphate biosynthesis.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 18 | Proton donor | |||
Binding site | 20 | substrate | |||
Binding site | 49 | substrate | |||
Binding site | 67 | substrate | |||
Binding site | 69 | substrate | |||
Binding site | 84 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3-dehydro-L-gulonate-6-phosphate decarboxylase activity | |
Molecular Function | carbon-nitrogen lyase activity | |
Molecular Function | hexulose-6-phosphate synthase activity | |
Molecular Function | hydro-lyase activity | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | carbohydrate biosynthetic process | |
Biological Process | L-ascorbic acid catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional enzyme Fae/Hps
Including 2 domains:
- Recommended name5,6,7,8-tetrahydromethanopterin hydro-lyase
- EC number
- Alternative names
- Recommended name3-hexulose-6-phosphate synthase
- EC number
- Short namesHPS
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageArchaea > Euryarchaeota > Archaeoglobi > Archaeoglobales > Archaeoglobaceae > Archaeoglobus
Accessions
- Primary accessionA0A101DCK3
Proteomes
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-162 | Formaldehyde-activating enzyme | |||
Region | 163-394 | 3-hexulose-6-phosphate synthase | |||
Domain | 175-377 | Orotidine 5'-phosphate decarboxylase | |||
Sequence similarities
In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length394
- Mass (Da)43,200
- Last updated2016-04-13 v1
- MD5 Checksum204A3343B3A9EF95259F0E3835DD39AF
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LGEQ01000036 EMBL· GenBank· DDBJ | KUJ93055.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LGEX01000048 EMBL· GenBank· DDBJ | KUK06194.1 EMBL· GenBank· DDBJ | Genomic DNA |