A0A0X8I8F2 · A0A0X8I8F2_9CREN
- ProteinGlycerol-1-phosphate dehydrogenase [NAD(P)+]
- GeneegsA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids351 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
Catalytic activity
- sn-glycerol 1-phosphate + NAD+ = dihydroxyacetone phosphate + NADH + H+
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Membrane lipid metabolism; glycerophospholipid metabolism.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 97-101 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 119-122 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 124 | glycerol (UniProtKB | ChEBI) | |||
Binding site | 124 | substrate | |||
Binding site | 128 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 171 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 171 | glycerol (UniProtKB | ChEBI) | |||
Binding site | 171 | substrate | |||
Binding site | 251 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 251 | glycerol (UniProtKB | ChEBI) | |||
Binding site | 255 | substrate | |||
Binding site | 267 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 267 | glycerol (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | glycerol-1-phosphate dehydrogenase (NAD+) activity | |
Molecular Function | glycerol-1-phosphate dehydrogenase (NADP+) activity | |
Molecular Function | metal ion binding | |
Biological Process | glycerophospholipid metabolic process | |
Biological Process | phospholipid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol-1-phosphate dehydrogenase [NAD(P)+]
- EC number
- Short namesG1P dehydrogenase ; G1PDH
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Acidilobales > Acidilobaceae > Acidilobus
Accessions
- Primary accessionA0A0X8I8F2
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length351
- Mass (Da)37,404
- Last updated2016-04-13 v1
- MD5 Checksum361975CB668858A43BE6A20C32825BC1
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP010515 EMBL· GenBank· DDBJ | AMD30416.1 EMBL· GenBank· DDBJ | Genomic DNA |