A0A0R2QSU4 · A0A0R2QSU4_9ACTN

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site17-20CoA (UniProtKB | ChEBI)
Binding site43CoA (UniProtKB | ChEBI)
Binding site100-102CoA (UniProtKB | ChEBI)
Binding site164substrate; ligand shared with subunit beta
Active site250Tele-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentsuccinate-CoA ligase complex (ADP-forming)
Molecular Functionnucleotide binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit alpha
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit alpha
      (SCS-alpha
      )

Gene names

    • Name
      sucD
    • ORF names
      ABR62_04435

Organism names

Accessions

  • Primary accession
    A0A0R2QSU4

Proteomes

Interaction

Subunit

Heterotetramer of two alpha and two beta subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-104CoA-binding

Sequence similarities

Belongs to the succinate/malate CoA ligase alpha subunit family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    293
  • Mass (Da)
    29,980
  • Last updated
    2016-01-20 v1
  • Checksum
    77026CE7E1B708D8
MAIFLTEKTKVIVQGITGSEGSKHTRRMILSGTNIVGGVTPGKGGQVVEIEGKSLPVFNSVTEAVAATGADASVIFVPPKFAKSAVIDAIDAHLPLIVVITEGIPVHDTASFYAHSLKVGKSRIIGPNCPGLISPGKSNIGITPADITGPGSIGLVSKSGTLTYQMMYELRDIGFTTAVGIGGDPIVGTTHIDCLRAFQDDPETKAIVMIGEIGGDAEERAAAFIKEYVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAEAKKVALEAAGVKVGKTPSQTAELLRAILKG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LIAU01000060
EMBL· GenBank· DDBJ
KRO53260.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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