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A0A0R2P4I1 · A0A0R2P4I1_9ACTN

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

167550100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site225-232ATP (UniProtKB | ChEBI)
Binding site447Zn2+ (UniProtKB | ChEBI); catalytic
Active site448
Binding site451Zn2+ (UniProtKB | ChEBI); catalytic
Binding site523Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      ABR60_00645

Organism names

Accessions

  • Primary accession
    A0A0R2P4I1

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-47Helical
Transmembrane133-155Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-22Disordered
Domain217-356AAA+ ATPase
Region633-675Disordered
Compositional bias658-675Basic and acidic residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    675
  • Mass (Da)
    73,714
  • Last updated
    2016-01-20 v1
  • MD5 Checksum
    D241C2F072F93434BF31B76AF5C5DB88
MADKKVKVKPPKLPAKSGKKPAPQKIFRRPLFWILVAIVGVTIFGQISSGSNQFTKIDTSKAMAAITRGDVESANIVDRDQKIQLVLKPGVAINGATKVEASYVTGQEPIIISLLTANQPAKEWDVTVPKVNILVSILFTLGPILLLAFLLLFFLSRSQGGSKVFSFGRSKAKLHDNEVPQTTFADVAGADEAIEEFREIKDFLAEPKKYQEIGAKIPKGVLLFGPPGTGKTLLARAVAGEAKVPFYSISGSDFVEMFVGVGAARVRDLFTQAKANAPAIIFVDEIDAVGRHRGAGMGGGHDEREQTLNQLLVEMDGFEAHEQVILIAATNRPDILDPALLRPGRFDRQIGVDRPDVKGREAIIKVHSKNKPLEKGLDLLAIARRTPGFTGADLANVLNEAALLTARENRKVISSTDVDEAIDRVMAGPQRKSRLMSEEERRVTAYHEGGHALVAHALPHTDPVHKITILPRGRALGYTMVLPDEDKYSTTRNQMLDQLAYTMGGRAAEELVFHDPTTGASNDIEKATALARAMVTQYGMTEKLGAIKLGNSDAAPFMGRDYGHQRDYSEDLAATIDQEIKNLIGQAHEEAYEILIENRSILDALVEELLEKETLQKEEIAAIFKHVASRPKRPAWTGSASRIPSRIPPVAIKARVNSKSDEGVKRKKKPPSKEA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias658-675Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LIAS01000052
EMBL· GenBank· DDBJ
KRO30845.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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