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A0A0R2P1V7 · A0A0R2P1V7_9ACTN

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12NAD+ (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site31NADPH (UniProtKB | ChEBI)
Binding site105NADPH (UniProtKB | ChEBI)
Binding site105sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site105substrate
Binding site135sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site139NAD+ (UniProtKB | ChEBI)
Binding site139NADPH (UniProtKB | ChEBI)
Active site190Proton acceptor
Binding site190sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site243sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site253sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site254NAD+ (UniProtKB | ChEBI)
Binding site254NADPH (UniProtKB | ChEBI)
Binding site254sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site254-255substrate
Binding site255sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site280NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionacyltransferase activity
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      ABR60_01060

Organism names

Accessions

  • Primary accession
    A0A0R2P1V7

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-159Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain179-319Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    334
  • Mass (Da)
    35,096
  • Last updated
    2016-01-20 v1
  • MD5 Checksum
    E4B6A1F1094EB495AE184977BD191DA9
MKVAVLGSGQWGSTLAQVLIDAGNEVIIWGRNKEVVDEINTKHSNSSALFEHFLPDGLSATRDIERALDGAELIVLAIPSQSLRENLLRWQGLISSDIAIVSTLKGIEISTQLRMSEVISQVLGRDSSMISVLTGPNLAREVILRQPAGAVAASTNQEVAELTAKAFSAPYFRVYTSNDVIGCELASAAKNVIAIAVGMSIGMGFGENTQALVITRGLNELTRLAIARGAAPLTFVGLAGVGDLLATCGSPLSRNRTFGEALGRSGSVEQAQRAISSTAEGLTTAQALVELAHLVGVEAPIMEAVCDVVTSKISPQQAILNLMKIQTGAEIDHV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LIAS01000035
EMBL· GenBank· DDBJ
KRO30978.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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