A0A0Q8Q197 · A0A0Q8Q197_9SPHN

Function

function

Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per monomer.
cob(II)alamin (UniProtKB | Rhea| CHEBI:16304 )

Pathway

tRNA modification; tRNA-queuosine biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site61cob(II)alamin (UniProtKB | ChEBI)
Active site136Proton donor
Binding site136cob(II)alamin (UniProtKB | ChEBI)
Binding site160cob(II)alamin (UniProtKB | ChEBI)
Binding site171cob(II)alamin (UniProtKB | ChEBI)
Binding site190[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site193[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site196[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site200[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site216[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site218cob(II)alamin (UniProtKB | ChEBI)
Binding site243[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site243-244cob(II)alamin (UniProtKB | ChEBI)
Binding site246[4Fe-4S] cluster 2 (UniProtKB | ChEBI)
Binding site250[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncobalamin binding
Molecular Functionepoxyqueuosine reductase activity
Molecular Functionmetal ion binding
Biological Processqueuosine biosynthetic process
Biological ProcesstRNA modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Epoxyqueuosine reductase
  • EC number
  • Alternative names
    • Queuosine biosynthesis protein QueG

Gene names

    • Name
      queG
    • ORF names
      ASE00_19935

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Root710
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingomonas

Accessions

  • Primary accession
    A0A0Q8Q197

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain181-2104Fe-4S ferredoxin-type

Sequence similarities

Belongs to the QueG family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    382
  • Mass (Da)
    41,232
  • Last updated
    2016-01-20 v1
  • Checksum
    1C590DE5E86F7F35
MTDDPTALREAVRAEALALGFAACGFARADAAPESAARLDDWLESGAHGSMEWMEARKHHRARPQGLWPEARSLIMLGMSYAPREDPLRLAAEPGIGRISVYAQGADYHDVVKKALKALARWLVDRAGGELKVFVDTAPVMEKPLSAAAGIGWQGKHSNLVSREHGSWLFLGAIMTSLDLPPDDAHDDRCGSCDACQFACPTSAFPRPYVVDARRCISYLTIEHHGPIPLEFRQAIGNRIYGCDDCLAVCPWNKFAEDAAANRAFAARAELAAPELIDLLGLDDAGFRAVFAGSPIKRIGRDRMIRNALIAAGNSGRGDLIPPVRALLDDPAAVVRGAAVWALARLDPLAFEAERPEREAEEPDPETRSEWNVAVAKAAAGG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LMIB01000018
EMBL· GenBank· DDBJ
KRB79379.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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