A0A0Q8Q196 · A0A0Q8Q196_9SPHN

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site98-100substrate
Binding site129-132substrate; in site B
Binding site139-141substrate
Binding site187substrate
Active site188Proton donor/acceptor
Active site319
Binding site320substrate
Binding site325-327substrate
Site332Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      ASE00_20000

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Root710
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingomonas

Accessions

  • Primary accession
    A0A0Q8Q196

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-343Fumarate lyase N-terminal
Domain409-461Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    463
  • Mass (Da)
    48,776
  • Last updated
    2016-01-20 v1
  • Checksum
    BC629EEB445136ED
MPDTRTETDSFGPIEVPAASYWGAQTQRSIENFPFGPEERMPIGIVHALALVKQAAAQVNRDHGLDAKLADAIEAAAAEVAAGKLDDHFPLVIWQTGSGTQSNMNVNEVIAGRANEMLTGQRGGKSPVHPNDHVNMGQSSNDSFPTALHVAAALAVHRRLYPALDAMLEELIAKAQDWDDIVKIGRTHLQDATPLTLGQEFSGYAAQLIACRKRLEGAVNGGMMKLAQGGTAVGTGLNAAPGFAEDVAARIAALTGLDFITAPNKFEALASNDPLVHLSGTLSTVAVALTKIANDIRLLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEMLTMVAAQVIGNHQAVTVGGLQGHLELNVFKPLIGAAVLRSIALLSVGMASFTQRALKGMEPDRQRIADLVGRSLMLVTALAPEIGYDNAAKIAKHAHHEGLTLKEAGLALGLIDEATFDRVVRPETMVGR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LMIB01000018
EMBL· GenBank· DDBJ
KRB79391.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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