A0A0N7GEL5 · A0A0N7GEL5_BOVIN
- ProteinNADH-ubiquinone oxidoreductase chain 4
- GeneND4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids222 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Catalytic activity
- a ubiquinone + NADH + 5 H+(in) = a ubiquinol + NAD+ + 4 H+(out)
a ubiquinone RHEA-COMP:9565 + CHEBI:57945 + 5 H+ (in)CHEBI:15378= a ubiquinol RHEA-COMP:9566 + CHEBI:57540 + 4 H+ (out)CHEBI:15378
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADH-ubiquinone oxidoreductase chain 4
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionA0A0N7GEL5
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 5-24 | Helical | |||
Transmembrane | 36-55 | Helical | |||
Transmembrane | 76-92 | Helical | |||
Transmembrane | 98-115 | Helical | |||
Transmembrane | 127-151 | Helical | |||
Transmembrane | 171-191 | Helical | |||
Keywords
- Cellular component
Interaction
Subunit
Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 1-91 | NADH:ubiquinone oxidoreductase chain 4 N-terminal | |||
Domain | 94-222 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | |||
Sequence similarities
Belongs to the complex I subunit 4 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length222
- Mass (Da)25,312
- Last updated2016-01-20 v1
- MD5 ChecksumE3D39F9E73074D7E5BA3263FFA82271A
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 222 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KP777014 EMBL· GenBank· DDBJ | ALH44142.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP777015 EMBL· GenBank· DDBJ | ALH44143.1 EMBL· GenBank· DDBJ | Genomic DNA |