A0A0N1LCE9 · A0A0N1LCE9_9PROT

  • Protein
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • Gene
    gpsA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8-13NAD+ (UniProtKB | ChEBI)
Binding site11NADPH (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site44NADPH (UniProtKB | ChEBI)
Binding site61NADPH (UniProtKB | ChEBI)
Binding site116NADPH (UniProtKB | ChEBI)
Binding site116sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site116substrate
Binding site144sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site146sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site148NAD+ (UniProtKB | ChEBI)
Binding site148NADPH (UniProtKB | ChEBI)
Active site199Proton acceptor
Binding site199sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site252sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site262sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site263NAD+ (UniProtKB | ChEBI)
Binding site263NADPH (UniProtKB | ChEBI)
Binding site263sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site263-264substrate
Binding site264sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site282NADPH (UniProtKB | ChEBI)
Binding site284NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • ORF names
      IP84_08310

Organism names

Accessions

  • Primary accession
    A0A0N1LCE9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_500587666820-334Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-167Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain188-322Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    334
  • Mass (Da)
    34,244
  • Last updated
    2015-12-09 v1
  • Checksum
    A540671DCE614215
MNHLVVVGAGSWGTALAMAALRSAAFFSAAGDQPPAARVTLLARDAAQAAAMQAQRENARYLSGIALPAALHISADAAVLHDASLVLLVTPFAGLREWFERLGTLGHAAPVLWAAKGMDAQSGEMAHELAARLLPGRACGVVSGPSFASEVARGLPCALTVASSSEALQQLGSQWLHGSTLRVYRSADVTGVEVGGAVKNVIAIATGMCDGLNLGLNARAALITRGLAEMSRFAVALGAKPETLAGLTGLGDLILTATGELSRNRRYGLEFARDGHAHGGFLAEGARCARAVQHRAAALGIEMPITACVADIVEGRLSPPAAAQQLLARAARAE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LJIA01000007
EMBL· GenBank· DDBJ
KPF68784.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help