A0A0N0P8A0 · A0A0N0P8A0_LEPSE

  • Protein
    Thymine dioxygenase JBP1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionthymine dioxygenase activity
Biological Processbase J metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thymine dioxygenase JBP1
  • EC number
  • Alternative names
    • J-binding protein 1
    • Thymidine hydroxylase JBP1

Gene names

    • ORF names
      ABL78_1199

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ATCC 30220
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leptomonas

Accessions

  • Primary accession
    A0A0N0P8A0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Monomer. Binds to DNA as a monomer.

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain107-2632OGFeDO JBP1/TET oxygenase
Domain397-558Thymine dioxygenase JBP1 DNA-binding
Compositional bias541-558Basic and acidic residues
Region541-571Disordered

Sequence similarities

Belongs to the TET family. JBP1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    824
  • Mass (Da)
    92,510
  • Last updated
    2015-12-09 v1
  • Checksum
    F2FE54340830E9A0
MEPGLKRAKLDIFSLPRGKSGHTPEEAAASYAEAVRSHPFYDNAHSIVDLYDSATLKDGKGRIIGVVLRKALPEFAASAAADLLISAAVRTSLRSPMFGGEAPLSGIAGYFDYRGSPVELKSRKTSFTYEHEKEWPAVFPLVDYVSAIYKCVMPEHWAAQNSAIPDIVRIHGTPFSTLTINSRFRTASHTDAGDFDGGYSCIACIDGNFKGLALTFDDFRVNVLLQPRDVLVFDSHHYHSNTEVEISCQSEDWKRLTCVFYYRSALGEPGSYAEYQRRLEAALQDKEAHPVVKEVAVKPNGENLNKPSPVFPIHLSPFAVITTLHRMRHCAAKALRVHELLIALYSTLSTTLFGEDLVCTDGIPLRGIDEKLKANADSTARPVSRLGGFSEAGAVLTTAAERRKYLEREYLSEFIAVELLEMWEQARAKWLDLVAKEWKHLVAISPKRTDFLWKNTSDMNAAFFDLCEVGKQIMLGLLEKETALPAEEETFWSMYAMHLYTACAEELGMPQDAMSLRKLNVKLKDFNFGGTRYFKDMPIKEQQRRMERKGRIEEARRRSSPTSSASSERRSSWLTNDSFDYQCEDCVVDYAKNEWPLPQCYAESVTMHVCKEDSTACWEPVGLLVVFPRPDGKGCGGVGDCKEEVKEEVKECVATSAEWMRLMSSSAVHRVLSSAQRNTSLPPDRSFDNVRVRFAYHDDLPDEKFDFVVLQHVLSVMPDDAVAATYVQGVGAVCSGCIFVVETDVQCRQYYTLKCPIRAEYDAVAPAFFQQLHRTSYGTERARMRTKAEIESLFPLPCVARYKLEGSPMNTVVHLLALEGEHTM

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias541-558Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LJSK01000018
EMBL· GenBank· DDBJ
KPI89706.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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