A0A0N0JTE2 · A0A0N0JTE2_9PROT

  • Protein
    Phosphoenolpyruvate carboxykinase [GTP]
  • Gene
    pckG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site82substrate
Binding site221-223substrate
Binding site230Mn2+ (UniProtKB | ChEBI)
Binding site258Mn2+ (UniProtKB | ChEBI)
Binding site280substrate
Binding site281-286GTP (UniProtKB | ChEBI)
Active site282
Binding site307Mn2+ (UniProtKB | ChEBI)
Binding site403-405substrate
Binding site405GTP (UniProtKB | ChEBI)
Binding site436GTP (UniProtKB | ChEBI)
Binding site537-540GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      IP84_14385

Organism names

Accessions

  • Primary accession
    A0A0N0JTE2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-242Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain254-625Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    629
  • Mass (Da)
    68,793
  • Last updated
    2015-12-09 v1
  • Checksum
    812AB23FDD3E66A3
MNAVLKPAVSAPDWVRHAKLIEWVHSIAAHTQPDRIYWCDGSQSEYDRLCGELVAAGTMRKLNDAKRPNSYLAWSDPSDVARVEDRTFICSENKEDAGPTNNWMAPTEMRATLDGLFAGCMRGRTMYVVPFSMGPLGSPIAHIGVELSDSPYVAVNMRIMTRMGRAVYDVLGADGEFVPCVHTVGKPLAAGDKDVPWPCNPTKYIVHFPETREIWSYGSGYGGNALLGKKCFALRIASTMGRQAAQRPSGSPGWLAEHMLVLGVTSPTGKKYHVAAAFPSACGKTNFAMLIPPAGFEGWKVTTIGDDIAWIKPGADGRLYAINPEAGYFGVAPGTNTLTNPNCMASLQRDVIFTNVALTDDGDVWWEGMEKETGGAPAHLIDWQGKDWTPEDGKAGRKAAHPNARFTVAATNNPALDAQWDDPAGVPIDAFIFGGRRSTVVPLVTEARNWVEGVYMAATMGSETTAAQAGATGVVRRDPFAMLPFAGYNMADYFQHWLNLGERLQASGAKLPKIFTTNWFRKGTEGEMSGKFIWPGYGENMRVLKWMIDRIEGTGGGSEHVFGISPRYEDLNWTGLPFSAQDFDKVTSIDRAAWQAELKLHEELFAQLAHRLPAQLPEVKAQIEARLAV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LJIA01000018
EMBL· GenBank· DDBJ
KPF67005.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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