A0A0N0JT79 · A0A0N0JT79_9PROT

  • Protein
    Phosphoribosylglycinamide formyltransferase
  • Gene
    purN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site33-35N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site86(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site128(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site130Proton donor
Site166Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • ORF names
      IP84_14860

Organism names

Accessions

  • Primary accession
    A0A0N0JT79

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-203Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    230
  • Mass (Da)
    24,369
  • Last updated
    2015-12-09 v1
  • Checksum
    BC6C0FB5268105D0
MSAPGPGRGFSPTPAYNRGVKHKNIAILISGRGSNMEAILKAHKAEQWPCKIVAVISSRPNAAGLDAARAAGIPTQVIDHKQFAGREAFDAMLKKTLEALRADYVILAGFMRVLSEGFVNSFRGRLVNIHPSLLPAFPGLATHRQALAAGVRVHGCTVHFVTPAVDGGPIIAQAIVPVMADDTEDSLADRVLAQEHKLLPAVVRALVEDRIAIEGRQVVVSGMPTLVVGS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LJIA01000019
EMBL· GenBank· DDBJ
KPF66788.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help