A0A0M3UA77 · A0A0M3UA77_9PSEU
- ProteinAdenosine deaminase
- Geneadd
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids367 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
Catalytic activity
- 2'-deoxyadenosine + H2O + H+ = 2'-deoxyinosine + NH4+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 24 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 26 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 26 | substrate | |||
Binding site | 28 | substrate | |||
Binding site | 186 | substrate | |||
Binding site | 213 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 216 | Proton donor | |||
Site | 237 | Important for catalytic activity | |||
Binding site | 304 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 2'-deoxyadenosine deaminase activity | |
Molecular Function | adenosine deaminase activity | |
Molecular Function | zinc ion binding | |
Biological Process | adenosine catabolic process | |
Biological Process | hypoxanthine salvage | |
Biological Process | inosine biosynthetic process | |
Biological Process | nucleotide metabolic process | |
Biological Process | purine ribonucleoside monophosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosine deaminase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Pseudonocardia
Accessions
- Primary accessionA0A0M3UA77
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 19-358 | Adenosine deaminase | |||
Sequence similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length367
- Mass (Da)39,634
- Last updated2015-12-09 v1
- MD5 ChecksumB1AC29F68A76931EC1ACB6C500CFCCAF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP011868 EMBL· GenBank· DDBJ | ALE82015.1 EMBL· GenBank· DDBJ | Genomic DNA |