Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A0M3UA77 · A0A0M3UA77_9PSEU

Function

function

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site24Zn2+ (UniProtKB | ChEBI); catalytic
Binding site26Zn2+ (UniProtKB | ChEBI); catalytic
Binding site26substrate
Binding site28substrate
Binding site186substrate
Binding site213Zn2+ (UniProtKB | ChEBI); catalytic
Active site216Proton donor
Site237Important for catalytic activity
Binding site304Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function2'-deoxyadenosine deaminase activity
Molecular Functionadenosine deaminase activity
Molecular Functionzinc ion binding
Biological Processadenosine catabolic process
Biological Processhypoxanthine salvage
Biological Processinosine biosynthetic process
Biological Processnucleotide metabolic process
Biological Processpurine ribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosine deaminase
  • EC number
  • Alternative names
    • Adenosine aminohydrolase

Gene names

    • Name
      add
    • ORF names
      XF36_01775

Organism names

  • Taxonomic identifier
  • Strain
    • HH130629-09
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Pseudonocardia

Accessions

  • Primary accession
    A0A0M3UA77

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain19-358Adenosine deaminase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    367
  • Mass (Da)
    39,634
  • Last updated
    2015-12-09 v1
  • MD5 Checksum
    B1AC29F68A76931EC1ACB6C500CFCCAF
MADPTAPVPVTPDTVRRAPKVLLHDHLDGGLRVGTVVELAREHGYDRLPTTDPGELAAWFLGAAHSGSLVRYLETFGHTVAVLQTREALTRVAAEAAEDLAADGVVYAEVRFAPELHVEGGLDLDAVIAAVLDGFRIGTARAAAAGSTIRIGTLLTAMRHAARSREIAELAVRHRDAGVVGFDIAGAEKGFPPTRHLDAFEYVRQQNAHVTIHAGEAFGLPSIWEAVQWCGADRLGHGVRIVDDITVTDGGPRLGRLAAWVRDSRIPLEMCPTSNVHTGAATSLAEHPIGLLTALRFRVTVNTDNRLMSGCTMTSEMYDLAETFGYGWDTLRWFTVNAMKSAFIGFDERLALIEDVIKPGYEALSRS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011868
EMBL· GenBank· DDBJ
ALE82015.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help