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A0A0L8VGJ6 · A0A0L8VGJ6_9SACH

Function

function

Maintains high levels of reduced glutathione in the cytosol.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site, active site.

146750100150200250300350400450
Type
IDPosition(s)Description
Binding site54FAD (UniProtKB | ChEBI)
Binding site188-195NAD+ (UniProtKB | ChEBI)
Binding site278NAD+ (UniProtKB | ChEBI)
Binding site318FAD (UniProtKB | ChEBI)
Active site456Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionglutathione-disulfide reductase (NADPH) activity
Molecular FunctionNADP binding
Biological Processcell redox homeostasis
Biological Processcellular response to oxidative stress
Biological Processglutathione metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione reductase
  • EC number

Gene names

    • ORF names
      KO01_05057

Organism names

  • Taxonomic identifier
  • Strain
    • Biocodex
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces

Accessions

  • Primary accession
    A0A0L8VGJ6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond45↔50Redox-active

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-333FAD/NAD(P)-binding
Domain356-466Pyridine nucleotide-disulphide oxidoreductase dimerisation

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    467
  • Mass (Da)
    51,563
  • Last updated
    2015-11-11 v1
  • MD5 Checksum
    C9B1329CD7375AFB794B265449986725
MSTNTKHYDYLVIGGGSGGVASARRAASYGAKTLLVEAKALGGTCVNVGCVPKKVMWYASDLATRVSHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVFGWARFNKDGNVEVQKRDNTTEVYSANHILVATGGKAIFPENIPGFELGTDSDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSETHLVVRGETVLRKFDECIQNTITDHYVKEGINVHKLSKIVKVEKNVETNKLKIHMNDSKSIDDVDELIWTIGRKSHLGMGSENVGIKLNSHDQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENVPSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSPTRYKIVCAGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTMR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LIIL01000028
EMBL· GenBank· DDBJ
KOH47287.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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