A0A0L8VGJ6 · A0A0L8VGJ6_9SACH
- ProteinGlutathione reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids467 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Maintains high levels of reduced glutathione in the cytosol.
Catalytic activity
- 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 54 | FAD (UniProtKB | ChEBI) | |||
Binding site | 188-195 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 278 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 318 | FAD (UniProtKB | ChEBI) | |||
Active site | 456 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | glutathione-disulfide reductase (NADPH) activity | |
Molecular Function | NADP binding | |
Biological Process | cell redox homeostasis | |
Biological Process | cellular response to oxidative stress | |
Biological Process | glutathione metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione reductase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionA0A0L8VGJ6
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 45↔50 | Redox-active | |||
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 8-333 | FAD/NAD(P)-binding | |||
Domain | 356-466 | Pyridine nucleotide-disulphide oxidoreductase dimerisation | |||
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length467
- Mass (Da)51,563
- Last updated2015-11-11 v1
- MD5 ChecksumC9B1329CD7375AFB794B265449986725
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LIIL01000028 EMBL· GenBank· DDBJ | KOH47287.1 EMBL· GenBank· DDBJ | Genomic DNA |