A0A0K2LC88 · A0A0K2LC88_9LACO
- ProteinATP-dependent helicase/nuclease subunit A
- GeneaddA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1226 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 23-30 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | DNA helicase complex | |
Molecular Function | 3'-5' DNA helicase activity | |
Molecular Function | 3'-5' exonuclease activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | double-stranded DNA binding | |
Molecular Function | isomerase activity | |
Biological Process | double-strand break repair via homologous recombination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent helicase/nuclease subunit A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Companilactobacillus
Accessions
- Primary accessionA0A0K2LC88
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-477 | UvrD-like helicase ATP-binding | |||
Domain | 514-812 | UvrD-like helicase C-terminal | |||
Compositional bias | 528-543 | Acidic residues | |||
Region | 528-549 | Disordered | |||
Sequence similarities
Belongs to the helicase family. AddA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,226
- Mass (Da)140,924
- Last updated2015-11-11 v1
- MD5 ChecksumC2D5BE7D36082032309766723548CC1B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 528-543 | Acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP012559 EMBL· GenBank· DDBJ | ALB28917.1 EMBL· GenBank· DDBJ | Genomic DNA |