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A0A0K2LC88 · A0A0K2LC88_9LACO

Function

function

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site23-30ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentDNA helicase complex
Molecular Function3'-5' DNA helicase activity
Molecular Function3'-5' exonuclease activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functiondouble-stranded DNA binding
Molecular Functionisomerase activity
Biological Processdouble-strand break repair via homologous recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent helicase/nuclease subunit A
  • EC number
  • Alternative names
    • ATP-dependent helicase/nuclease AddA
    • DNA 3'-5' helicase AddA

Gene names

    • Name
      addA
    • ORF names
      JP39_05825

Organism names

Accessions

  • Primary accession
    A0A0K2LC88

Proteomes

Subcellular Location

Interaction

Subunit

Heterodimer of AddA and AddB/RexB.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain2-477UvrD-like helicase ATP-binding
Domain514-812UvrD-like helicase C-terminal
Compositional bias528-543Acidic residues
Region528-549Disordered

Sequence similarities

Belongs to the helicase family. AddA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,226
  • Mass (Da)
    140,924
  • Last updated
    2015-11-11 v1
  • MD5 Checksum
    C2D5BE7D36082032309766723548CC1B
MPKWTADQKKAIEHRGHDILVSAAAGSGKTTILIERILRELIGDEDHQPEDIEHLLVVTFTEAAAQEMKEKLLRALKKEVNKTQDSEIKHHLQKQIYHVPMANISTIHAFCLSVIKKFYYVIDLDPNFRLLSDDTEKSIIQEQAYDLIRDEYYSKDDADFIDLTNNFTNDRSDDGLKDVIFKTYDFAITNRDTDTWLDNLVTPYQFKDSFIETDFYKQEFLPQIKQRLEDLRQYNRETVDFVGNDELANSYMPVLRERDEKIGHLEESMSQMSYQELREELMTFKIDAKKDKVGKADKEGKDDTLMKAAGKMASNFTTRRNKLIEDYFMRSEDEINQSLRDAEGLINKLVEVERRFIKKFDDLKTNSHVLDFNDLEHKAVDILNGAVDGRKIAQEFYQNKFNELMIDEYQDVNEMQDRIVDLLSCDSNHRFMVGDIKQSIYGFRQAAPRLFTEKYDRFQRDDNDAELVQLSKNFRSSKAVDDFVNQIFTRIFDKQIGDIDYDEKAKLVTGTSFPDSVDTENEFNVYLAPDDEDDGEEPTDELNEESLSNQAEISKRQTLISAAATKIQSLISSGFEIYDSKMDKDTEAEKIRPLKYSDIAILARTRDNNTDIVSYFSKVNVPVMVTDAQNYFQTTELQIMMAMLNIVDNPYQDIPLVAVLRSPIVGLNEEELAEIRLVDKRNMYYTAIQKYLNQEDANEHIQNKLKSFLLQLENYRDFANKNSIARLIWKIYQETGLLEYVSGMPGGKQRAANLHALYQRANAYEENNFKGLHQFISFIQRMQDLDKDLAQPNSIEANDDTVKVMTVHGSKGLEFPIVMYLDMSKNFNMMDVNSNTVFDAQKGIGITLADNETRLQYRTMQRGVISNQKKISTVSEEMRLLYVALTRAKQKLIMFGFAKDESKLFQAFDKPATGGLLNASARLGANNFQNLVGMSTLNGVDTEEYYDDEIKLRFNVIPVAATTNQAKEIIIPKAAPEPINETFKKSVSGILDFKYPYQESVETTAYQSVSEIKGLFADPDDENMAEDLLEDRYRYNLGSFDKPQFLTQSKKVTNTEVGSATHLVLQKISIEKTPTVVDFDELIQDLVNQKLLTDELAEKIDRQGLADFYQSDLGQLIVQNHERVSREFPCSILMPAEKLFKTDIKDYSTNDKILVHGIIDGVIELDSGITIFDYKTDHVTAENHSELISKYSGQVNLYAEAISAIKNQPVEGKYLYFLKTNEAVSL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias528-543Acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP012559
EMBL· GenBank· DDBJ
ALB28917.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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