A0A0H3GWQ6 · A0A0H3GWQ6_KLEPH
- Protein16S rRNA (guanine(1405)-N(7))-methyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids251 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Specifically methylates the N7 position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides.
Catalytic activity
- guanosine1405 in 16S rRNA + S-adenosyl-L-methionine = N7-methylguanosine1405 in 16S rRNA + S-adenosyl-L-homocysteine
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 81-87 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 111 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 131 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
Binding site | 157-158 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | rRNA methyltransferase activity | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name16S rRNA (guanine(1405)-N(7))-methyltransferase
- EC number
Gene names
Encoded on
- Plasmid pKPHS3
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A0H3GWQ6
Proteomes
Structure
Family & Domains
Sequence similarities
Belongs to the methyltransferase superfamily. Aminoglycoside resistance family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length251
- Mass (Da)27,408
- Last updated2015-09-16 v1
- Checksum8D5464F4B4D60B50
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP003225 EMBL· GenBank· DDBJ | AEW92264.1 EMBL· GenBank· DDBJ | Genomic DNA |