A0A0F0HKE9 · A0A0F0HKE9_9ACTN

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

167450100150200250300350400450500550600650
Type
IDPosition(s)Description
Binding site213-220ATP (UniProtKB | ChEBI)
Binding site435Zn2+ (UniProtKB | ChEBI); catalytic
Active site436
Binding site439Zn2+ (UniProtKB | ChEBI); catalytic
Binding site511Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcell division
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      UK14_02120

Organism names

  • Taxonomic identifier
  • Strain
    • NRRL F-4428
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A0F0HKE9

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-34Helical
Transmembrane121-141Helical

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain205-344AAA+ ATPase
Region622-674Disordered
Compositional bias626-658Polar residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    674
  • Mass (Da)
    72,978
  • Last updated
    2015-06-24 v1
  • Checksum
    365247E2DECCC9DD
MDVKRYFRGPVMWIVLAVLAVVVLMNVVGSGGGYKSVDTSEVIKAINTGQVETAKLTTGDSQMIKIELKQGQKLGKHDGTKFQANYIGDQGVQLAQNLQTKYDAGQIPDGYSVTPDKTSPFLSVLLSLLPFVLIVVVFLFLMNQMQGGGSRVMNFGKSKAKLITKDTPKTTFADVAGSDEAVEELHEIKEFLQEPAKFQAVGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFYSISGSDFVEMFVGVGASRVRDLFEQAKANAPAIVFVDEIDAVGRHRGAGLGGGHDEREQTLNQLLVEMDGFDVKGGVILIAATNRPDILDPALLRPGRFDRQIAVDRPDMQGRLEILKVHQKGKPVAPDVDLGAVARRTPGFTGADLSNVLNEAALLTARSDKKLIDNHMLDEAIDRVVAGPQKRTRIMSDREKKITAYHEGGHALVAAASPNSDPVHKITILSRGRALGYTMVLPDEDKYSTTRNEMLDQLAYMLGGRAAEELVFHDPTTGAANDIEKATATARAMVTQYGMTERLGAIKFGGDNTEPFLGREMSHPRDYSEEVAALVDEEVKKLIETAHNEAWEILVENRDVLDNLVLALLEKETLGKEEIAEIFSTIVKRPARPAWTGSSRRTPSTRPPVLSPKELQLTNAANGSASVAPVSTEKGIEVAPEDRPE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias626-658Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JYJI01000007
EMBL· GenBank· DDBJ
KJK54303.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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