A0A0E3XRG0 · A0A0E3XRG0_MYCCH
- ProteinMultifunctional 2-oxoglutarate metabolism enzyme
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1127 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- 2-oxoglutarate + H+ = succinate semialdehyde + CO2
Cofactor
Protein has several cofactor binding sites:
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinate from 2-oxoglutarate (transferase route): step 1/2.
Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | oxoglutarate dehydrogenase complex | |
Molecular Function | 2-hydroxy-3-oxoadipate synthase activity | |
Molecular Function | 2-oxoglutarate decarboxylase activity | |
Molecular Function | dihydrolipoyllysine-residue succinyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | oxoglutarate dehydrogenase (succinyl-transferring) activity | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional 2-oxoglutarate metabolism enzyme
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillati > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacteroides
Accessions
- Primary accessionA0A0E3XRG0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for coiled coil, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Coiled coil | 681-708 | ||||
Domain | 771-970 | Transketolase-like pyrimidine-binding | |||
Sequence similarities
Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,127
- Mass (Da)125,091
- Last updated2015-06-24 v1
- MD5 Checksum1A56155E8261A2E130D07DAADE0CED7F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MLIS01000001 EMBL· GenBank· DDBJ | OHU80485.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MLCH01000013 EMBL· GenBank· DDBJ | OLT75711.1 EMBL· GenBank· DDBJ | Genomic DNA |