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A0A0E2L976 · A0A0E2L976_ECOU3

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site37-385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site695-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site69GMP (UniProtKB | ChEBI)
Binding site88-965-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site89Mg2+ (UniProtKB | ChEBI)
Binding site92guanine (UniProtKB | ChEBI)
Binding site92xanthine (UniProtKB | ChEBI)
Binding site92-96GMP (UniProtKB | ChEBI)
Binding site134-135GMP (UniProtKB | ChEBI)
Binding site135guanine (UniProtKB | ChEBI)
Binding site135xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • ORF names
      G925_00261

Organism names

Accessions

  • Primary accession
    A0A0E2L976

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-143Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    152
  • Mass (Da)
    16,984
  • Last updated
    2015-05-27 v1
  • MD5 Checksum
    84B4AA49C6CC2EC10CA1215ADD15A8E0
MSEKYIVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFITIFAKPAGRPLVDDYVVDIPQNTWIEQPWDMGVVFVPPISGR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AWBU01000003
EMBL· GenBank· DDBJ
EQX32686.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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