A0A0D1DQL7 · A0A0D1DQL7_USTMA

Function

function

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleotide-excision repair factor 3 complex
Cellular Componenttranscription factor TFIIH core complex
Cellular Componenttranscription factor TFIIH holo complex
Molecular FunctionRNA polymerase II general transcription initiation factor activity
Molecular Functiontranslation initiation factor activity
Molecular Functionubiquitin protein ligase activity
Molecular Functionzinc ion binding
Biological Processnucleotide-excision repair
Biological Processregulation of transcription by RNA polymerase II
Biological Processtranscription initiation at RNA polymerase II promoter

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    General transcription and DNA repair factor IIH

Gene names

    • ORF names
      UMAG_10551

Organism names

Accessions

  • Primary accession
    A0A0D1DQL7

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain, zinc finger.

Type
IDPosition(s)Description
Region1-78Disordered
Compositional bias12-29Acidic residues
Compositional bias55-78Polar residues
Domain148-324VWFA
Zinc finger397-414C4-type

Sequence similarities

Belongs to the GTF2H2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    516
  • Mass (Da)
    55,397
  • Last updated
    2015-04-29 v1
  • Checksum
    9B0F3C33D248560C
MPPRIADDEYIDDGAGAYDAEDFLDDDDSGDEYRAAPSLPKLGTLRGAGAGGASRSSAAASNGRAGTLAAGSSASSSGTARAKAAANAKSKQKDQGYSWEATYKRSWDAVAEDDSGSLESTVRSMIEGSKRRRVLKDVAPVQRGIIRHLVLLIDLSASMLEKDMRPNRFDVTLQYAREFVGEYFDQNPIGQLSIIGTRSGIAERLAMMGGNTVDHTASLSNKRRLEPRGEPSLQNALEMARSSLVHLPASNSREILAIFGSLTTCDPGNIHDTIATLVKDNIRVSIVHLAAEVKVFKDVCTRTGGTFSVALNEGHFHDSLFELVPPPAVEGKPRRTRQHMVGIADGSTAMDAEDDDEDGVQAGVDLLQMAFPLRLPAHAAPTLCACHSRSRGSGYLCPRCGVKVCNVPTDCPVCGITIVMSTHLARSYHHLFPVPNWKAVPWSSVTPDSDGACFSCNVPFPSLQERKEKSAAANKALEEAGLSPSSRYRCGRCAIDFCLECDAFVHEQLHVCPGCC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias12-29Acidic residues
Compositional bias55-78Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM003158
EMBL· GenBank· DDBJ
KIS66281.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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