A0A0C1D2N9 · A0A0C1D2N9_9SPHI

  • Protein
    Lipoprotein signal peptidase
  • Gene
    lspA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

120020406080100120140160180200
TypeIDPosition(s)Description
Active site131
Active site165

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      OC25_22995

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KACC 16221
  • Taxonomic lineage
    Bacteria > Bacteroidota > Sphingobacteriia > Sphingobacteriales > Sphingobacteriaceae > Pedobacter

Accessions

  • Primary accession
    A0A0C1D2N9

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane62-82Helical
Transmembrane94-115Helical
Transmembrane155-178Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    200
  • Mass (Da)
    22,832
  • Last updated
    2015-04-01 v1
  • Checksum
    69C5A08AE0C4EF06
MKGYTKPLILIFLVLLADQLIKTWVKTHMYLGQEFHIIGKWCIIHFTENNGMAFGMEFGGEFGKLALSLFRIAAVGGIGYGLHYLIKHKYHRGLILNVALIFSGALGNIIDSVFYGKIYGYESWFHGRVVDMFYFPIAEGHFPSWFPIWGGEEFVFFRPVFNLADAAISVGVILILIFQKNYFKEDVKDDVSINSEIVED

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JSYN01000034
EMBL· GenBank· DDBJ
KIA91136.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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