A0A0C1D243 · A0A0C1D243_9SPHI

  • Protein
    3-isopropylmalate dehydratase large subunit
  • Gene
    leuC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site346[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site406[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site409[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3-isopropylmalate dehydratase activity
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionisomerase activity
Molecular Functionmetal ion binding
Biological ProcessL-leucine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-isopropylmalate dehydratase large subunit
  • EC number
  • Alternative names
    • Alpha-IPM isomerase
      (IPMI
      )
    • Isopropylmalate isomerase

Gene names

    • Name
      leuC
    • ORF names
      OC25_23940

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KACC 16221
  • Taxonomic lineage
    Bacteria > Bacteroidota > Sphingobacteriia > Sphingobacteriales > Sphingobacteriaceae > Pedobacter

Accessions

  • Primary accession
    A0A0C1D243

Proteomes

Interaction

Subunit

Heterodimer of LeuC and LeuD.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-456Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha

Sequence similarities

Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    468
  • Mass (Da)
    50,789
  • Last updated
    2015-04-01 v1
  • Checksum
    49E657205A062BB6
MSKTLVEKIWDAHVVKSEEGFPDILYIDTHLIHEVTSPQAFDGLRKRGLPVFRPKQTVATADHNVPTLNQLLPIKEELSRYQVDMLTKNCAEFGVELYGLGHPFQGIVHVIGPELGITLPGKTMVCGDSHTSTHGAFGAIAFGIGTSQVEQVFATQCLLQSKPKTMKIEVNGELGKGVGAKDIILYIIAQISAAGGTGYFIEYAGSAIESLSMEARMTICNMSIEMGARGGLIAPDQITFDYIKGREFAPAGEEWDKALAYWKTLYSDADAKFDSVLTFNAADIAPMITYGTNPGMGMGIQEHIPATAAQPETEKVSYKKALDYMGFDDDAALIGKPIDYVFIGSCTNSRIEDLREVANFVKDKHKAENVTVWIVPGSKQVEQQAKNEGLDKIFEAAGFQLREPGCSACLGMNEDKIPAGKYCVSTSNRNFEGRQGQNARTLLASPLTAAAAAVTGKITDVREMLEKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JSYN01000037
EMBL· GenBank· DDBJ
KIA90951.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help