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A0A066SS77 · A0A066SS77_ECOLX

  • Protein
    Quinate/shikimate dehydrogenase
  • Gene
    ydiB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD or NADP for catalysis, however it has higher catalytic efficiency with NAD.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site71substrate
Binding site107substrate
Binding site132-135NAD+ (UniProtKB | ChEBI)
Binding site155-158NAD+ (UniProtKB | ChEBI)
Binding site205NAD+ (UniProtKB | ChEBI)
Binding site232-235NAD+ (UniProtKB | ChEBI)
Binding site255NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionquinate 3-dehydrogenase (NAD+) activity
Molecular Functionquinate 3-dehydrogenase (NADP+) activity
Molecular Functionshikimate 3-dehydrogenase (NAD+) activity
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Quinate/shikimate dehydrogenase
  • EC number
  • Alternative names
    • NAD-dependent shikimate 5-dehydrogenase

Gene names

    • Name
      ydiB
    • ORF names
      EPS76_02695
      , GRC73_18370
      , HIE29_000965
      , OGM49_12805
      , R8O40_000789

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 1924188
    • C0382
    • EC00763
    • 29_CAASB
    • S7
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A066SS77

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-94Shikimate dehydrogenase substrate binding N-terminal
Domain255-284SDH C-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    288
  • Mass (Da)
    31,229
  • Last updated
    2014-09-03 v1
  • MD5 Checksum
    8E5691E64A8DB12E1A1B740A3BB3C27B
MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPFTYMAFEVDNDSFPGAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIKGKTMVLLGAGGASTAIGAQGAIEGLKEIKLFNRRDEFFDKALAFAQRVNENTDCVVTVTDLADQQAFAEALASADILTNGTKVGMEPLENESLVNDISLLHPGLLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFTLWTGKDFPLEYVKQVMGFGA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ABONVU020000002
EMBL· GenBank· DDBJ
EMJ5252613.1
EMBL· GenBank· DDBJ
Genomic DNA
DABBJX010000023
EMBL· GenBank· DDBJ
HAH4525949.1
EMBL· GenBank· DDBJ
Genomic DNA
DABCJL010000002
EMBL· GenBank· DDBJ
HAH7767610.1
EMBL· GenBank· DDBJ
Genomic DNA
SCJN01000010
EMBL· GenBank· DDBJ
RXD17875.1
EMBL· GenBank· DDBJ
Genomic DNA
CP107128
EMBL· GenBank· DDBJ
WLM98268.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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