W9VSZ0 · W9VSZ0_9EURO
- ProteinHistone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids532 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | histone binding | |
Molecular Function | nucleosome binding |
Names & Taxonomy
Protein names
- Recommended nameHistone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Chaetothyriomycetidae > Chaetothyriales > Herpotrichiellaceae > Cladophialophora
Accessions
- Primary accessionW9VSZ0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 54-85 | Disordered | ||||
Sequence: DDPASKRRKLPNGGATATTTTTLPITPAHKDQ | ||||||
Compositional bias | 65-80 | Polar residues | ||||
Sequence: NGGATATTTTTLPITP | ||||||
Domain | 244-345 | Histone chaperone RTT106/FACT complex subunit SPT16-like middle | ||||
Sequence: AYHVKAHRGSKDGYLFFLSNGIFFGFKKPLAFFAFEDIESISYTSVLQRTFNLNIAHRPSGSGEADDNANAIQEVEFSMLDQADFVGIDEYVKRHGLQDASL | ||||||
Region | 347-532 | Disordered | ||||
Sequence: EARRAKKSATNAKPGGIQNGDPAGEGEGEDPDTRTELEKAQQQLDDEEDEDEEDYDPGSDGESEGSGSSDDDDDDDDREYERERKKSKGKDLVKEELGSEAEDVSVTEDEDEGEGEGEAENGDELEDEGDKEEQPGANDRDRHDRTPGKRDPNARRGGPTIASIPSHDGGWTYQEGMPDPDDEDQL | ||||||
Compositional bias | 373-387 | Basic and acidic residues | ||||
Sequence: EGEDPDTRTELEKAQ | ||||||
Compositional bias | 388-424 | Acidic residues | ||||
Sequence: QQLDDEEDEDEEDYDPGSDGESEGSGSSDDDDDDDDR | ||||||
Compositional bias | 425-447 | Basic and acidic residues | ||||
Sequence: EYERERKKSKGKDLVKEELGSEA | ||||||
Compositional bias | 448-478 | Acidic residues | ||||
Sequence: EDVSVTEDEDEGEGEGEAENGDELEDEGDKE | ||||||
Compositional bias | 479-498 | Basic and acidic residues | ||||
Sequence: EQPGANDRDRHDRTPGKRDP |
Sequence similarities
Belongs to the RTT106 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length532
- Mass (Da)58,574
- Last updated2014-05-14 v1
- Checksum0D6E2D097D071E20
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 65-80 | Polar residues | ||||
Sequence: NGGATATTTTTLPITP | ||||||
Compositional bias | 373-387 | Basic and acidic residues | ||||
Sequence: EGEDPDTRTELEKAQ | ||||||
Compositional bias | 388-424 | Acidic residues | ||||
Sequence: QQLDDEEDEDEEDYDPGSDGESEGSGSSDDDDDDDDR | ||||||
Compositional bias | 425-447 | Basic and acidic residues | ||||
Sequence: EYERERKKSKGKDLVKEELGSEA | ||||||
Compositional bias | 448-478 | Acidic residues | ||||
Sequence: EDVSVTEDEDEGEGEGEAENGDELEDEGDKE | ||||||
Compositional bias | 479-498 | Basic and acidic residues | ||||
Sequence: EQPGANDRDRHDRTPGKRDP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AMGW01000004 EMBL· GenBank· DDBJ | EXJ58683.1 EMBL· GenBank· DDBJ | Genomic DNA |