W5P9G9 · W5P9G9_SHEEP

  • Protein
    Insulin-induced gene protein
  • Gene
    INSIG1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Mediates feedback control of cholesterol synthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentSREBP-SCAP-Insig complex
Molecular Functionoxysterol binding
Molecular Functionprotein sequestering activity
Biological Processcholesterol biosynthetic process
Biological Processcholesterol homeostasis
Biological Processcranial suture morphogenesis
Biological Processinner ear morphogenesis
Biological Processmiddle ear morphogenesis
Biological Processnegative regulation of cargo loading into COPII-coated vesicle
Biological Processnegative regulation of fat cell differentiation
Biological Processnegative regulation of fatty acid biosynthetic process
Biological Processnegative regulation of protein exit from endoplasmic reticulum
Biological Processnegative regulation of steroid biosynthetic process
Biological Processroof of mouth development
Biological ProcessSREBP signaling pathway
Biological ProcessSREBP-SCAP complex retention in endoplasmic reticulum
Biological Processtriglyceride metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Insulin-induced gene protein

Gene names

    • Name
      INSIG1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Texel
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis

Accessions

  • Primary accession
    W5P9G9
  • Secondary accessions
    • A0A6P3YHJ9

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane88-106Helical
Transmembrane126-146Helical
Transmembrane182-203Helical
Transmembrane210-229Helical
Transmembrane241-262Helical

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the INSIG family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    276
  • Mass (Da)
    29,638
  • Last updated
    2014-04-16 v1
  • Checksum
    9A94F2E23C4191FF
MPRLDDHLWRGPCAKGTKHRSHPRASTRGLVAKAGEMINSSGSGPSLLAAHGAPGTDPAHGLQSTGVGGQGSSGHVNSWHHHLVQRSLVLFSVGVVLALVLNLLQVQRNVTLFPDEVIATIFSSAWWVPPCCGTAAAVVGLLYPCIDSHLGEPHKFKREWASVMRCVAVFVGINHASAKLDFANNVQLSLTLAALSLGLWWTFDRSRSGLGLGITIAFLATLITQLLVYNGVYQYTSPDFLYIRSWLPCIFFSGGVTVGNIGRQLAMGVPEKPHSD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AMGL01090145
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AMGL01090146
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AMGL01090147
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AMGL01090148
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AMGL01090149
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AMGL01090150
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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