W0DBY5 · W0DBY5_9AQUI

  • Protein
    Delta-aminolevulinic acid dehydratase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Catalytic activity

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Features

Showing features for binding site, active site.

132750100150200250300
TypeIDPosition(s)Description
Binding site120Zn2+ (UniProtKB | ChEBI); catalytic
Binding site122Zn2+ (UniProtKB | ChEBI); catalytic
Binding site130Zn2+ (UniProtKB | ChEBI); catalytic
Active site195Schiff-base intermediate with substrate
Binding site2055-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site2175-aminolevulinate 1 (UniProtKB | ChEBI)
Binding site233Mg2+ (UniProtKB | ChEBI)
Active site248Schiff-base intermediate with substrate
Binding site2745-aminolevulinate 2 (UniProtKB | ChEBI)
Binding site3135-aminolevulinate 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionmetal ion binding
Molecular Functionporphobilinogen synthase activity
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta-aminolevulinic acid dehydratase
  • EC number

Gene names

    • ORF names
      THERU_02570

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 23557
  • Taxonomic lineage
    Bacteria > Aquificota > Aquificia > Aquificales > Aquificaceae > Thermocrinis

Accessions

  • Primary accession
    W0DBY5

Proteomes

Interaction

Subunit

Homooctamer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ALAD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    327
  • Mass (Da)
    36,544
  • Last updated
    2014-03-19 v1
  • Checksum
    458B5EA0163EBA96
MEFPKLRPRRLRLSENIRRLVRETRLTLDDLIYPIFVRYGENIVEEVPSMPGVYRYSVDRVVDAVKEVRDLGIPAIILFGIPEHKDEIGSDTWSEQGIIQRALRRIKKEVPEMYVITDVCFCEYTTHGHCGVLKGHTVDNDLTLENLKKQVISHAENGADMVAPSGMMDGMVQAIRSALDSAGYTHIPIMAYSAKFASAFYGPFRDAAESAPAFGDRRSYQMDPANAREALKEVLLDVQEGADIVMVKPALAYLDIIAKVKEATLIPVCAYNVSGEYAMIKAAGRLGWIDEEKVMIETLISIKRAGADMIITYFAKDVAKLINKGII

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP007028
EMBL· GenBank· DDBJ
AHE95746.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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