V7HCW1 · V7HCW1_9HYPH

Function

function

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site13-18ATP (UniProtKB | ChEBI)
Binding site17Mg2+ (UniProtKB | ChEBI)
Active site33
Binding site37substrate
Binding site44ATP (UniProtKB | ChEBI)
Binding site44Mg2+ (UniProtKB | ChEBI)
Binding site100Mg2+ (UniProtKB | ChEBI)
Binding site100-103ATP (UniProtKB | ChEBI)
Binding site184-186ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functiondethiobiotin synthase activity
Molecular Functionmagnesium ion binding
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent dethiobiotin synthetase BioD
  • EC number
  • Alternative names
    • DTB synthetase
      (DTBS
      )
    • Dethiobiotin synthase

Gene names

    • Name
      bioD
    • ORF names
      X728_32080

Organism names

  • Taxonomic identifier
  • Strain
    • L103C120A0
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Phyllobacteriaceae > Mesorhizobium

Accessions

  • Primary accession
    V7HCW1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the dethiobiotin synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    211
  • Mass (Da)
    22,413
  • Last updated
    2014-02-19 v1
  • Checksum
    EDF1519C3225E278
MTQRIVITGTDTGVGKTVFAAGLAGLLDGFYWKPVQSGLDGETDSEVVARLAGLPSERVLPEAYRLRSPLSPHRSAEIDGVAIKAADLAFPVLPTPLVIEGSGGLMVPLNRRTRLIDIFAEWRLPVILCARTTLGTINHTLLSVEALRARSIPLAGIAFIGDEMADTQRTIVEFSGAPQLGRLPHLDVLTGKTLRDAMVAGFAFASITGGD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AYXD01000028
EMBL· GenBank· DDBJ
ESZ54139.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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