V7F2S6 · V7F2S6_9HYPH
- ProteinPhosphopantetheine adenylyltransferase
- GenecoaD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids166 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Catalytic activity
- (R)-4'-phosphopantetheine + ATP + H+ = 3'-dephospho-CoA + diphosphate
Cofactor
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 11 | substrate | ||||
Sequence: S | ||||||
Binding site | 11-12 | ATP (UniProtKB | ChEBI) | ||||
Sequence: SF | ||||||
Binding site | 19 | ATP (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 19 | Transition state stabilizer | ||||
Sequence: H | ||||||
Binding site | 43 | substrate | ||||
Sequence: K | ||||||
Binding site | 80 | substrate | ||||
Sequence: V | ||||||
Binding site | 94 | substrate | ||||
Sequence: R | ||||||
Binding site | 95-97 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GLR | ||||||
Binding site | 105 | ATP (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 130-136 | ATP (UniProtKB | ChEBI) | ||||
Sequence: VRTITAT |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | pantetheine-phosphate adenylyltransferase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphopantetheine adenylyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Phyllobacteriaceae > Mesorhizobium
Accessions
- Primary accessionV7F2S6
Proteomes
Subcellular Location
Interaction
Subunit
Homohexamer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-140 | Cytidyltransferase-like | ||||
Sequence: LYAGSFDPLTNGHLDVLKASLAVADTVYAAIGTHPGKTPLFSFDERVKLIEAATKAEFGRDGDRIKVVAFDGLVIDAARKHGASIMIRGLRDGTDLDYEMQMAGMNETMAPELQTVFLPASPSVRTITATLVRQ |
Sequence similarities
Belongs to the bacterial CoaD family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length166
- Mass (Da)17,667
- Last updated2014-02-19 v1
- Checksum09A473FF9032FD42
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AYVQ01000011 EMBL· GenBank· DDBJ | ESX24377.1 EMBL· GenBank· DDBJ | Genomic DNA |