U3FAJ6 · U3FAJ6_MICFL

Function

function

Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbicellular tight junction
Cellular Componentendoplasmic reticulum membrane
Cellular Componentplasma membrane
Molecular FunctionFFAT motif binding
Biological Processneuron projection development

Names & Taxonomy

Protein names

  • Recommended name
    Vesicle-associated membrane protein-associated protein A

Organism names

Accessions

  • Primary accession
    U3FAJ6

Subcellular Location

Cell junction, tight junction
Cell membrane
; Single-pass type IV membrane protein
Endoplasmic reticulum membrane
; Single-pass type IV membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane227-247Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain13-130MSP
Coiled coil172-199

Sequence similarities

Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    248
  • Mass (Da)
    27,727
  • Last updated
    2013-11-13 v1
  • Checksum
    7EADF6CEF6977A77
MAAAGVLAKHEQILVLDPPTDLKFKGPFTDVVITNLKLRNPSDRKVCFKVKTTAPRRYCVRPNSGIIDPGTSVTVSVMLQPFDYDPNEKSKHKFMVQTIFAPTNITDMEAVWKDAKSEELMDSKLRCVFEMPNENDKLNEIETSKSAPILNTTKQDGLLPKSHSVSLNDTETRKLVEECKRLQADIVKLSEENRHLRDEGLRLRKVSHSDKPGPSGLALRDNGSNPLPSLLVVIAAIFIGFFLGKFIL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GAEP01001892
EMBL· GenBank· DDBJ
JAB52929.1
EMBL· GenBank· DDBJ
mRNA
GBEW01001204
EMBL· GenBank· DDBJ
JAI09161.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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