T5D914 · T5D914_HELPX
- ProteinAdenylosuccinate lyase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids440 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarateThis reaction proceeds in the forward direction.
Pathway
Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.
Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity | |
Molecular Function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity | |
Biological Process | 'de novo' AMP biosynthetic process | |
Biological Process | 'de novo' IMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylosuccinate lyase
- EC number
- Short namesASL
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionT5D914
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 349-439 | Adenylosuccinate lyase C-terminal | ||||
Sequence: GGLVFSQRVLLELPKKGLSREESYLIVQENAMKIWEVLQQGAFKNADENLFLNALLNDERLKQYLSEDEIKACFDYGYYTKNVGAIFKKVF |
Sequence similarities
Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length440
- Mass (Da)49,982
- Last updated2013-11-13 v1
- Checksum87646A6CC8F35C05
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AKHS02000012 EMBL· GenBank· DDBJ | EQL67331.1 EMBL· GenBank· DDBJ | Genomic DNA |