S7MVD9 · S7MVD9_MYOBR

Function

function

Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex. Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles. Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi apparatus
Biological Processprotein ubiquitination

Names & Taxonomy

Protein names

  • Recommended name
    EARP and GARP complex-interacting protein 1
  • Alternative names
    • Endosome-associated recycling protein-interacting protein
    • Golgi-associated retrograde protein-interacting protein
    • Tumor-suppressing STF cDNA 1 protein
    • Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein

Gene names

    • ORF names
      D623_10020892

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Myotis

Accessions

  • Primary accession
    S7MVD9

Proteomes

Subcellular Location

Interaction

Subunit

Interacts with two multisubunit tethering complexes: EARP composed of VPS50, VPS51, VPS52 and VPS53 subunits and GARP complex composed of VPS51, VPS52, VPS53 and VPS54 subunits. Interacts with SNAP29.

Family & Domains

Features

Showing features for repeat, region, compositional bias.

TypeIDPosition(s)Description
Repeat209-245WD
Region294-323Disordered
Compositional bias296-318Basic and acidic residues

Sequence similarities

Belongs to the WD repeat EIPR1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    372
  • Mass (Da)
    41,294
  • Last updated
    2013-10-16 v1
  • Checksum
    475549F3CB39428E
MRGSEQDHAALGSVAVAGLPVASAEASVYHACSAARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQVGEIWHISASPADKGVLATCYNKRGGLGSGSSVLTRVLPLSVVWEPTGDGTRVVSLADNHLLLWDLQASSSRALLASSASLEGKGQLRFTSGRWSPHHNCTQVATANDTAVRGWDTRSMRQIYCMENAHGQLVRDLDFNPNKQYYLATCGDDCKVKFWDTRNVTEPVRSLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDLSDQEERRPEDKSQEPPQDGVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVINRVPRALKYHILL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias296-318Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KE162477
EMBL· GenBank· DDBJ
EPQ08449.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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