S0DQI7 · LAEA_GIBF5

Function

function

Methyltransferase that performs automethylation (By similarity).
No other methyl-accepting substrate has been identified yet (By similarity).
Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:20572938).
Controls the expression of the gibberellins gene clusters, but does not affect bikaverin production (PubMed:20572938).
Controls the expression of the fusaric acid gene cluster (PubMed:24389666).
Acts as a virulence factors during infection, most likely through activation of gibberellins biosynthesis (PubMed:20572938).

Catalytic activity

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionmethyltransferase activity
Biological Processmethylation
Biological Processsporulation resulting in formation of a cellular spore

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Secondary metabolism regulator LAE1
  • Alternative names
    • Methyltransferase LAE1
      (EC:2.1.1.-
      ) . EC:2.1.1.- (UniProtKB | ENZYME | Rhea)
    • Velvet complex subunit LAE1

Gene names

    • Name
      LAE1
    • ORF names
      FFUJ_00592

Organism names

Accessions

  • Primary accession
    S0DQI7
  • Secondary accessions
    • E0WDF6

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Reduces gibberellins production and subsequent virulence during infection (PubMed:20572938).
Reduces both the fusaric acid gene cluster expression and production of fusaric acid (PubMed:24389666).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004357491-316Secondary metabolism regulator LAE1

Expression

Induction

Expression is regulated by the VEL1 (PubMed:20572938).

Interaction

Subunit

Component of the heterotrimeric velvet complex composed of LAE1, VEL1 and VEL2; VEL1 acting as a bridging protein between LAE1 and VEL2 (By similarity).
Interacts with VEL1 (PubMed:20572938).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    316
  • Mass (Da)
    36,624
  • Last updated
    2016-03-16 v2
  • Checksum
    4657FCFE4FFDB2DA
MVVMPPQNSVNESEGRYLQDGFWQHGRFYGSWKPGKYLFPIDSEELNRLDIFHKVFLLARDNKPFLAPIRRTSPRIMDIGTGTGIWAINVAEECLSDAQIMAVDLNQIQPALIPPGFMPKQYDIEEPSWGPLLADCDLIHMRMLLGSIQTDLWPQVYHNAFEHLTPGIGFLEHIEVDWIPRCDDDERPANSAFVKWAELFLDGMDRFNRSVRVIPQEHRQMLEATGFTDVKQEVIKAYVCPWSADRNEREIARWFNIGLSHSLEAMSLKPLIEKLGFEAEDVRELCERAKRETCVLRYHTYCNIHVWTARKPGPQQ

Sequence caution

The sequence CCT62818.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN548141
EMBL· GenBank· DDBJ
CBE54370.1
EMBL· GenBank· DDBJ
Genomic DNA
HF679023
EMBL· GenBank· DDBJ
CCT62818.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

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