R7BB86 · R7BB86_9FIRM

Function

function

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13NAD+ (UniProtKB | ChEBI)
Binding site34NAD+ (UniProtKB | ChEBI)
Binding site85-87NAD+ (UniProtKB | ChEBI)
Binding site109-112NAD+ (UniProtKB | ChEBI)
Active site142Proton donor/acceptor
Binding site143(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)
Active site146Proton donor
Binding site152-153(S)-2,3,4,5-tetrahydrodipicolinate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate reductase
Molecular FunctionNAD binding
Molecular FunctionNADP binding
Molecular Functionoxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate reductase
  • EC number
  • Short names
    HTPA reductase

Gene names

    • Name
      dapB
    • ORF names
      BN614_01242

Organism names

Accessions

  • Primary accession
    R7BB86

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-112Dihydrodipicolinate reductase N-terminal
Domain115-248Dihydrodipicolinate reductase C-terminal

Sequence similarities

Belongs to the DapB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    250
  • Mass (Da)
    27,391
  • Last updated
    2013-07-24 v1
  • Checksum
    A8DF2C5050053C7D
MTKLIITGANGKMGKVIKSIVENRDDCEIVAGVDLNTDDNGAFPIYSSINDIKESADAIIDFSNPVLLNDLLSYSEKTSTPLVIATTGYSDEQKKQIAQASKTTPIFFTYNMSMGVNLLANLAKKAVEVLGDDFDIEIVEKHHNQKIDAPSGTALMLADAMCEEIEKPMKYEYDRHSKREKRTKNEIGIHAVRGGTIVGEHEIIFAGRDEIITLSHSARSKEIFAVGAVNAAVYMNGKGAGLYDMKELID

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CBHK010000004
EMBL· GenBank· DDBJ
CDD62787.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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