R4ISW0 · R4ISW0_TADBR

Function

function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentconnexin complex
Molecular Functiongap junction channel activity
Biological Processcell-cell signaling

Names & Taxonomy

Protein names

  • Recommended name
    Gap junction protein

Gene names

    • Name
      Gja10

Organism names

Accessions

  • Primary accession
    R4ISW0

Subcellular Location

Cell junction, gap junction
Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-35Helical
Transmembrane87-113Helical
Transmembrane145-170Helical

Keywords

Interaction

Subunit

A connexon is composed of a hexamer of connexins.

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain102-168Gap junction protein cysteine-rich
Region327-362Disordered
Compositional bias336-352Basic and acidic residues
Region375-397Disordered
Compositional bias378-397Polar residues

Sequence similarities

Belongs to the connexin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    397
  • Mass (Da)
    45,695
  • Last updated
    2013-07-24 v1
  • Checksum
    B36C0545C73B3CFC
YDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKERQRKKSHLRTHMENPGLELEEQQRIDRELRKLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYILYGFQMHSLYKCTRPPCPNAVDCFVSRPTEKTIFMLFMHSIAALSLFLNILEIFHLGIRKIMRALYEKPDNEGIEDDRGPPFHLRKYSVPQKCMICSPWPERISPLEASHQQQVVQVNVPKSKTLWQIPQPKHLEADLCSSKNDWAEKDQHRGQLHVHSPCPWDDCVRIQHLGQQPDHSSYGTQNTTSQSWLGTATAPRHCPSYAIGTWGQSQDLQPSGESLTDLHSHCRDSDGSVRESGVWTDRSRSGSRKASFLSRLLSEKGQLHSDAGSSSSRNSSYLDFPH

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias336-352Basic and acidic residues
Compositional bias378-397Polar residues
Non-terminal residue397

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC211204
EMBL· GenBank· DDBJ
AGB96831.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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