Q9ZZY1 · NU5M_HIPAM

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial respiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, NADH to ubiquinone
Biological Processmitochondrial respiratory chain complex I assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 5
  • EC number
  • Alternative names
    • NADH dehydrogenase subunit 5

Gene names

    • Name
      MT-ND5
    • Synonyms
      MTND5, NADH5, ND5

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Ancodonta > Hippopotamidae > Hippopotamus

Accessions

  • Primary accession
    Q9ZZY1

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1-21Helical
Transmembrane43-63Helical
Transmembrane87-107Helical
Transmembrane114-134Helical
Transmembrane137-157Helical
Transmembrane171-191Helical
Transmembrane211-233Helical
Transmembrane241-261Helical
Transmembrane272-292Helical
Transmembrane301-320Helical
Transmembrane325-347Helical
Transmembrane366-386Helical
Transmembrane409-429Helical
Transmembrane457-477Helical
Transmembrane486-506Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001180991-594NADH-ubiquinone oxidoreductase chain 5

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 5 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    594
  • Mass (Da)
    66,599
  • Last updated
    1999-05-01 v1
  • Checksum
    4130499096B5A5CE
MNLFSSTTLTMLFVLTLPIMMTNTNIYKSDKYPTYVKNTVSSAFLISLVPMIAFTNTGQEMIISNWHWITIQTLKLTLSFKADYFSIVFAPVALFVTWSIMEFSMWYMHSDPHINQFFKYLLLFLITMMILVTANNLFQLFIGWEGVGIMSFLLIGWWHGRTDANTAAIQAILYNRIGDVGFIMAMAWFLSNLNTWDMQQIFMINPTHSNLPLMGLILAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFYPMMENNNLMQTITMCLGAITTLFTAMCALTQNDIKKIIAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLFKTMPFTTTTLIVGSMALTGVPFLTGFYSKDLIIEAANTSYSNAWALLITLVATSLTAVYSTRIIFFALLGHPRFPTSTLIHENNPLLLNSLKRLMAGSIFAGFILSHNLPPMTTPLMTMPPYLKMTALAVTMLGFTLAFEITLNTQNLKYKHPTNSFKFSTLLGYFPTIMHRLPPHLSLTASQKLASSLLDSAWLENILPKSMAHAQLKLSTLVSNQKGLMKMYFSIIPYH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ010957
EMBL· GenBank· DDBJ
CAA09438.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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