Q9YGA5 · TF2B2_HALVD
- ProteinTranscription initiation factor IIB 2
- Genetfb2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids332 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
Miscellaneous
There are 6-12 TFIIB paralogs in this organism.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | transcription preinitiation complex | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | TBP-class protein binding | |
Molecular Function | zinc ion binding | |
Biological Process | transcription preinitiation complex assembly |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscription initiation factor IIB 2
- Short namesTFIIB 2
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Haloferacaceae > Haloferax
Accessions
- Primary accessionQ9YGA5
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000119319 | 1-332 | Transcription initiation factor IIB 2 | |||
Sequence: MSDTITTRTYSADAKSRDVRPRESERDETQQDETQVCPECSGHLVTDEEHGETICEDCGLVVEDTVVDRGPEWRAFDSAERDSKSRVGAPTTKMMHDKGLSTNIGWQNKDAYGKSLSPRQREQMQRLRTWNERFRTRDSKERNLKQALGEIDRMASALGLPENVRETASVIYRRALNDDLLPGRSIEGVATSALYASARMAGTPRSLDELEKVSRVDKMELTRTYRYIVRELKLEIKPADPEQYVPRFASELGLSDEAERQARQLLRDAKETGIHSGKSPVGLAAAAVYAAALLTNEKVTQSEVSTVADISEVTIRNRYKELLEVQDGTLLA |
Proteomic databases
Expression
Induction
By heat shock (60 degrees Celsius), with a 2-fold increase (at protein level).
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-36 | Disordered | ||||
Sequence: MSDTITTRTYSADAKSRDVRPRESERDETQQDETQV | ||||||
Compositional bias | 13-33 | Basic and acidic residues | ||||
Sequence: DAKSRDVRPRESERDETQQDE | ||||||
Zinc finger | 33-63 | TFIIB-type | ||||
Sequence: ETQVCPECSGHLVTDEEHGETICEDCGLVVE | ||||||
Region | 77-106 | Disordered | ||||
Sequence: DSAERDSKSRVGAPTTKMMHDKGLSTNIGW | ||||||
Repeat | 149-232 | 1 | ||||
Sequence: GEIDRMASALGLPENVRETASVIYRRALNDDLLPGRSIEGVATSALYASARMAGTPRSLDELEKVSRVDKMELTRTYRYIVREL | ||||||
Repeat | 243-324 | 2 | ||||
Sequence: QYVPRFASELGLSDEAERQARQLLRDAKETGIHSGKSPVGLAAAAVYAAALLTNEKVTQSEVSTVADISEVTIRNRYKELLE |
Sequence similarities
Belongs to the TFIIB family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length332
- Mass (Da)37,282
- Last updated1999-11-01 v1
- ChecksumBAA4118B60EF3323
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 13-33 | Basic and acidic residues | ||||
Sequence: DAKSRDVRPRESERDETQQDE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF143693 EMBL· GenBank· DDBJ | AAD43074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP001956 EMBL· GenBank· DDBJ | ADE05068.1 EMBL· GenBank· DDBJ | Genomic DNA |