Q9UYX0 · TDH_PYRAB

Function

function

Catalyzes the NAD+-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.

Features

Showing features for binding site, active site, site.

134850100150200250300
TypeIDPosition(s)Description
Binding site42Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site44Charge relay system
Active site47Charge relay system
Binding site67Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site68Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site97Zn2+ 2 (UniProtKB | ChEBI)
Binding site100Zn2+ 2 (UniProtKB | ChEBI)
Binding site103Zn2+ 2 (UniProtKB | ChEBI)
Binding site111Zn2+ 2 (UniProtKB | ChEBI)
Site152Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Binding site179NAD+ (UniProtKB | ChEBI)
Binding site199NAD+ (UniProtKB | ChEBI)
Binding site204NAD+ (UniProtKB | ChEBI)
Binding site266-268NAD+ (UniProtKB | ChEBI)
Binding site291-292NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenyl nucleotide binding
Molecular Functionanion binding
Molecular FunctionL-threonine 3-dehydrogenase activity
Molecular Functionzinc ion binding
Biological ProcessL-threonine catabolic process to glycine
Biological Processprotein tetramerization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-threonine 3-dehydrogenase
  • EC number
  • Short names
    TDH

Gene names

    • Name
      tdh
    • ORF names
      PAB2382
    • Ordered locus names
      PYRAB13870

Organism names

Accessions

  • Primary accession
    Q9UYX0
  • Secondary accessions
    • G8ZHJ3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001608751-348L-threonine 3-dehydrogenase

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    348
  • Mass (Da)
    37,744
  • Last updated
    2000-05-01 v1
  • Checksum
    91A8ED13DC4B7AD8
MSEKMVAIMKTKPAYGAELVEVDVPKPGPGEVLIKVIATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVVEVGPGVEGIEVGDYVSVETHIVCGKCYACRRGQYHVCQNTKIFGVDTDGVFAEYAVVPAQNVWKNPKSIPPEYATLQEPLGNAVDTVLAGPISGKSVLITGAGPLGLLGIAVAKASGAYPVIVSEPSDFRRELAKKVGADYVINPFEEDVVKEVMDITDGNGVDVFLEFSGAPKALEQGLQAVTPAGRVSLLGLYPGKVSIDFNNLIIFKALTVYGITGRHLWETWYTVSRLLQSGKLNLDPIITHKYKGFDKYEEAFELMRAGKTGKVVFMLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ248287
EMBL· GenBank· DDBJ
CAB50292.1
EMBL· GenBank· DDBJ
Genomic DNA
HE613800
EMBL· GenBank· DDBJ
CCE70830.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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