Q9TA00 · CYB_LAMFL
- ProteinCytochrome b
- Genemt-cyb
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids396 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Miscellaneous
Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
Cofactor
Note: Binds 2 heme b groups non-covalently.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 87 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 101 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 186 | Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 200 | Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue | ||||
Sequence: H | ||||||
Binding site | 205 | a ubiquinone (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial respiratory chain complex III | |
Molecular Function | metal ion binding | |
Molecular Function | ubiquinol-cytochrome-c reductase activity | |
Biological Process | mitochondrial electron transport, ubiquinol to cytochrome c |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCytochrome b
- Alternative names
Gene names
Encoded on
- Mitochondrion
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Cyclostomata > Hyperoartia > Petromyzontiformes > Petromyzontidae > Lampetra
Accessions
- Primary accessionQ9TA00
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 37-57 | Helical | ||||
Sequence: FGSLLSLCLILQIITGLILAM | ||||||
Transmembrane | 81-102 | Helical | ||||
Sequence: WLMRNLHANGASMFFICIYAHI | ||||||
Transmembrane | 117-137 | Helical | ||||
Sequence: WNVGVILFALTAATAFVGYVL | ||||||
Transmembrane | 182-202 | Helical | ||||
Sequence: FFTFHFILPFILAAMTMIHIM | ||||||
Transmembrane | 230-250 | Helical | ||||
Sequence: FKDIFGFVILLGVLFMISLLP | ||||||
Transmembrane | 292-312 | Helical | ||||
Sequence: LGGVMALAAAIMILLVIPFTH | ||||||
Transmembrane | 324-344 | Helical | ||||
Sequence: LAQVTFWILIADLALLTWLGG | ||||||
Transmembrane | 351-371 | Helical | ||||
Sequence: FILMTQIASTVYFMIFILIFP |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000061084 | 1-396 | Cytochrome b | |||
Sequence: MSHPPTILRKTHPLLSLGNSMLVDLPSPANISAWWNFGSLLSLCLILQIITGLILAMHYTANTELAFSSVMHICRDVNNGWLMRNLHANGASMFFICIYAHIGRGIYYGSYLYKETWNVGVILFALTAATAFVGYVLPWGQMSFWGATVITNLISAVPYVGDDIVMWLWGGFSVSNATLTRFFTFHFILPFILAAMTMIHIMFLHQTGSSNPLGINSNLDKIQFHPYFSFKDIFGFVILLGVLFMISLLPPNALCEPDNFIYANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVMALAAAIMILLVIPFTHTSKQRGIQFRPLAQVTFWILIADLALLTWLGGEPAEHPFILMTQIASTVYFMIFILIFPILGRLENKLILLSKNTGKFNWNLTY |
Interaction
Subunit
The cytochrome bc1 complex contains 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and probably 6 low-molecular weight proteins.
Structure
Sequence
- Sequence statusComplete
- Length396
- Mass (Da)44,542
- Last updated2000-05-01 v1
- ChecksumB2E69A5CB1C3304C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y18683 EMBL· GenBank· DDBJ | CAB62226.1 EMBL· GenBank· DDBJ | Genomic DNA |